手足口病合并肺炎支原体感染患儿实验室指标检测的临床意义  

Clinical Significance of Laboratory Test Indexes in Children with Hand-foot-and-mouth Disease Complicated Mycoplasma Pneumoniae Infection

作　　者：胡妞 HU Niu(Songzi People’s Hospital,Songzi 434200,China)

机构地区：[1]松滋市人民医院,湖北松滋434200

出　　处：《中外医学研究》2021年第15期75-78,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:探讨手足口病(HFMD)合并肺炎支原体(MP)感染患儿实验室检测指标对疾病诊疗的临床意义。方法:选择2018年12月-2019年11月本院诊治的HFMD合并MP感染的患儿158例为研究对象。根据病情严重程度分为重症组(65例)和轻症组(93例),采用荧光定量RT-PCR法检测肠道病毒71(EV71)和柯萨奇病毒A16(CA16)阳性表达率,常规监测血压、心率、空腹血糖(FBG)、白细胞(WBC)计数,采用免疫抑制法测定心肌酶谱[门冬氨酸氨基转移酶(AST)、肌酸激酶同工酶(CK-MB)、肌酸激酶(CK)、乳酸脱氢酶(LDH)、乳酸脱氢酶同工酶1(LDH-1)]水平,比较两组各检测指标。结果:重症组与轻症组EV71阳性率[90.77%(59/65)vs 27.96%(26/93)]、收缩压[(94.75±6.23)mm Hg vs(86.25±5.74)mm Hg]、舒张压[(65.18±7.43)mm Hg vs(56.64±5.16)mm Hg]、心率[(145.39±11.28)次/min vs(120.17±10.63)次/min]、WBC计数[(13.73±4.16)×10^(9)/L vs(10.09±2.54)×10^(9)/L]、FBG[(7.23±1.85)mmol/L vs(4.74±1.06)mmol/L]、AST[(56.73±7.68)U/L vs(46.17±6.49)U/L]、CK[(151.94±16.81)U/L vs(125.76±23.47)U/L]、CK-MB[(64.34±11.17)U/L vs(49.65±7.38)U/L]、LDH[(503.56±112.78)U/L vs(437.89±92.74)U/L]、LDH-1[(106.72±43.87)U/L vs(89.76±33.75)U/L]比较差异均有统计学意义(P<0.05);重症组与轻症组CA16阳性率比较差异无统计学意义(P>0.05)。结论:HFMD合并MP感染重症与轻症患儿实验室检测指标呈现出明显的差异,各检测指标对HFMD合并MP感染的诊疗具有重要的指导意义。Objective:To explore the clinical significance of laboratory test indexes in the children with hand-foot-and-mouth disease(HFMD)complicated mycoplasma pneumoniae(MP)infection.Method:The 158 children with HFMD and MP diagnosed and treated in our hospital from December 2018 to November 2019 were selected.According to the illness severity they were divided into the severe group(65 cases)and the mild group(93 cases).Used the fluorescence quantitative RT-PCR method to detect enterovirus 71(EV71)and coxsackie virus A16(CA16)positive expression rate,blood pressure,heart rate,fasting blood-glucose(FBG)and white blood cell(WBC)counts were routinely monitored,myocardial enzyme spectrum[aspartate transaminase(AST),creatine kinase isoenzyme(CK-MB),creatine Kinase(CK),lactate dehydrogenase(LDH),lactate dehydrogenase 1(LDH-1)]levels were determined by immunosuppression method,compared the detection indexes between the two groups.Result:There were significant differences in EV71 positive rate[90.77%(59/65)vs 90.77%(26/93)],systolic blood pressure[(94.75±6.23)mm Hg vs(86.25±5.74)mm Hg],diastolic blood pressure[(65.18±7.43)mm Hg vs(56.64±5.16)mm Hg],heart rate[(145.39±11.28)times/min vs(120.17±10.63)times/min],WBC count[(13.73±4.16)×10^(9)/L vs(10.09±2.54)×10^(9)/L],FBG[(7.23±1.85)mmol/L vs(4.74±1.06)mmol/L],AST[(56.73±7.68)U/L vs(46.17±6.49)U/L],CK[(151.94±16.81)U/L vs(125.76±23.47)U/L],CK-MB[(64.34±11.17)U/L vs(49.65±7.38)U/L],LDH[(503.56±112.78)U/L vs(437.89±92.74)U/L],LDH-1[(106.72±43.87)U/L vs(89.76±33.75)U/L]between the severe group and the mild group(P<0.05).There were no significant differences in the positive rate of CA16 between the severe group and the mild group(P>0.05).Conclusion:There are significant differences in the laboratory detection indexes between severe and mild cases of HFMD complicated with MP infection,and the detection indexes have important guiding significance for the diagnosis and treatment of HFMD complicated with MP infection.

关 键 词：手足口病 肺炎支原体 肠道病毒71 柯萨奇病毒A16 心肌酶谱 实验室指标 

分 类 号：R725.6[医药卫生—儿科] R725.1[医药卫生—临床医学]