血小板反应蛋白2及N末端-脑钠肽前体在射血分数保留型心力衰竭中的临床价值  

The Clinical Value of TSP-2 and NT-proBNP in Heart Failure with Preserved Ejection Fraction

作　　者：夏泉 杨静[1] 李从圣 王勇 朱毅 陶红 张中明 XIA Quan;YANG Jing;LI Congsheng;WANG Yong;ZHU Yi;TAO Hong;ZHANG Zhongming(Third Affiliated Hospital of Anhui Medical University,Hefei 230061,China;不详)

机构地区：[1]安徽医科大学第三附属医院合肥市第一人民医院,安徽合肥230061

出　　处：《中外医学研究》2021年第15期187-189,共3页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:研究血小板反应蛋白2(TSP-2)及N末端-脑钠肽前体(NT-proBNP)的水平对射血分数保留型心衰(HFpEF)患者预后的临床价值。方法:选取2018年9月-2019年9月于安徽医科大学第三附属医院就诊的91例HFpEF患者作为研究对象,同期43名健康者作为对照组,检测血清TSP-2及NT-proBNP水平。随访HFpEF组患者1年,记录主要不良心血管事件(MACE)发生情况,再分为MACE(-)组和MACE(+)组,通过单因素分析和多因素回归分析找出独立危险因素。最后通过ROC曲线评价各因素预测MACE的价值。结果:MACE(+)组TSP-2、NT-proBNP水平高于MACE(-)组,差异有统计学意义(P<0.05)。多因素回归分析结果显示,NT-proBNP、TSP-2均为HFpEF患者MACE发生的独立危险因素(OR=1.001,P=0.001;OR=1.213,P=0.001)。ROC曲线分析显示,TSP-2、NT-proBNP、TSP-2+NT-proBNP预测MACE曲线下面积分别为0.851、0.862、0.919。结论:TSP-2、NT-proBNP对HFpEF患者MACE发生有一定的预测价值,二者联合预测效果更佳。Objective:To study the clinical value of thrombospondin 2 (TSP-2) and N-terminal-brain natriuretic peptide (NT-proBNP) levels on the prognosis of patients with preserved ejection fraction heart failure (HFpEF).Method:Ninety-one patients with HFpEF who were treated in the Third Affiliated Hospital of Anhui Medical University from September 2018 to September 2019 were selected as the research subjects,and 43 healthy subjects were used as the control group during the same period to detect serum TSP-2 and NT-proBNP levels.Patients in the HFpEF group were followed up for 1 year,and the occurrence of major adverse cardiovascular events (MACE) was recorded,and then divided into MACE (-) group and MACE (+) group,and independent risk factors were found through univariate analysis and multivariate regression analysis.Finally,the ROC curve was used to evaluate the value of each factor predicting MACE.Result:TSP-2,NT-proBNP level of MACE (+) group were higher than MACE (-) group,the difference was statistically significant (P<0.05).The results of multivariate regression analysis showed,NT-proBNP and TSP-2 were both independent risk factors for MACE in HFpEF patients (OR=1.001,P=0.001;OR=1.213,P=0.001).ROC curve analysis showed TSP-2,NT-proBNP,TSP-2+NT-proBNP predicted the area under the MACE curve 0.851,0.862,0.919,respectively.Conclusion:TSP-2 and NT-proBNP have certain predictive value for the occurrence of MACE in patients with HFpEF,and the combination of the two has a better predictive effect.

关 键 词：TSP-2 NT-PROBNP 预后 临床价值 HFpEF 

分 类 号：R541.6[医药卫生—心血管疾病]