硫酸氯吡格雷联合阿司匹林肠溶片治疗急性心肌梗死的临床效果  

Clinical Effect of Clopidogrel Bisulfate Combined with Aspirin Enteric Coated Tablets in the Treatment of Acute Myocardial Infarction

作　　者：黎浩光 LI Haoguang(Nansha Hospital,Guangzhou First People’s Hospital,Guangzhou 510000,China)

机构地区：[1]广州市第一人民医院南沙医院,广东广州510000

出　　处：《中外医学研究》2021年第16期16-19,共4页CHINESE AND FOREIGN MEDICAL RESEARCH

摘　　要：目的:观察氯吡格雷联合阿司匹林肠溶片治疗急性心肌梗死的临床效果。方法:将本院2018年10月-2019年10月收治诊断为急性心肌梗死的患者共62例。按照随机数字表法分为对照组(阿司匹林肠溶片)和试验组(硫酸氯吡格雷联合阿司匹林肠溶片),各31例。对比两组治疗前后心脏血容量指标[左室舒张末期容积(LVEDV)、每搏输出量(SV)、下腔静脉管径(IVC)]、心脏功能指标[心输出量(CO)、左室射血分数(LVEF)]、6 min步行距离、生活质量,以及临床疗效、心血管不良事件。结果:治疗前两组心脏血容量及心脏功能指标、6 min步行距离比较差异无统计学意义(P>0.05)。治疗后,两组LVEDV水平均较治疗前下降,试验组低于对照组,两组SV、IVC及心脏功能指标、6 min步行距离较治疗前升高,试验组高于对照组(P<0.05)。试验组治疗总有效率(93.55%)高于对照组(74.19%),心血管不良事件发生率(6.45%)低于对照组(29.03%),差异均有统计学意义(P<0.05)。治疗前两组世界卫生组织生存质量简表(WHOQOL-BREF)评分比较差异无统计学意义(P>0.05);治疗后,两组WHOQOL-BREF评分较治疗前明显升高,试验组WHOQOL-BREF各项评分明显高于对照组(P<0.05)。结论:在急性心肌梗死的临床治疗中,使用氯吡格雷联合阿司匹林肠溶片,可有效地改善患者心脏血容量及心脏功能指标,提升患者6 min步行距离,心血管不良事件发生率更低,疗效更佳,且可改善生活质量,效果理想。Objective:To observe the clinical effect of Clopidogrel Bisulfate combined with Aspirin Enteric Coated Tablets in the treatment of acute myocardial infarction.Method:A total of 62 patients with acute myocardial infarction diagnosed in our hospital from October 2018 to October 2019 were randomly divided into the control group(Aspirin Enteric Coated Tablets)and the experimental group(Clopidogrel Bisulfate combined with Aspirin Enteric Coated Tablets),with 31 cases in each group.The cardiac volume indexes[left ventricular end-diastolic volume(LVEDV),stroke volume(SV),inferior vena cava diameter(IVC)],cardiac function indexes[cardiac output(CO),left ventricular ejection fraction(LVEF)],6 min walking distance and quality of life before and after treatment,and clinical efficacy and cardiovascular adverse events were compared between the two groups.Result:There were no significant differences in the cardiac volume and cardiac function and 6 min walking distance before treatment between the two groups(P>0.05);after treatment,the LVEDV level of both groups was lower than that before treatment,the LVEDV level in the experimental group was lower than that of the control group,the SV,IVC and cardiac function indexes,6 min walking distance of the experimental group were higher than those before treatment,the indexes in the experimental group were higher than those in the control group(P<0.05).The total effective rate of the experimental group(93.55%)was higher than that of the control group(74.19%),while the incidence of cardiovascular adverse events(6.45%)was lower than 29.03%of the control group(P<0.05).There were no significant differences in the world health organization quality of life(WHOQOL-BREF)scores between the two groups before treatment(P>0.05);after treatment,the scores of WHOQOL-BREF of the two groups were significantly higher than those before treatment,the scores of WHOQOL-BREF in the experimental group were significantly higher than those in the control group(P<0.05).Conclusion:In the clinical treatment of ac

关 键 词：硫酸氯吡格雷 阿司匹林肠溶片 联合治疗 急性心肌梗死 临床效果 

分 类 号：R542.22[医药卫生—心血管疾病]