信必可持续吸入对支气管哮喘出院患者主客观指标、运动耐受能力、生活质量和复发率的影响  

Effects of Xinbike continuous inhalation on subjective and objective indexes,exercise tolerance,quality of life and recurrence rate of discharged patients with bronchial asthma

作　　者：张春明 王素平[1] 彭想想 Zhang Chun-ming;Wang Su-ping;Peng Xiang-xiang(General Medicine Department of Lu'an People's Hospital,Lu'an 237005,China)

机构地区：[1]六安市人民医院全科医学科,六安237005

出　　处：《湖南师范大学学报（医学版）》2021年第3期63-66,共4页Journal of Hunan Normal University(Medical Sciences)

基　　金：安徽省六安市人民医院新技术新项目(2020kykt17)。

摘　　要：目的:探讨信必可持续吸入对支气管哮喘出院患者主客观指标、运动耐受能力、生活质量和复发率的影响。方法:选择2015年11月~2019年12月在我院就诊的支气管哮喘患者155例作为研究对象,随机数表法分为2组,对照组77例选择布地奈德吸入治疗,实验组78例选择信必可持续吸入治疗。比较两组治疗前后临床症状积分、肺功能指标、血清炎症因子水平,复发率和运动耐受能力、生活质量评分。结果:治疗后,实验组日间、夜间咳嗽积分均低于对照组;治疗后,实验组肺活量(VC)、第一秒用力呼气量(FEV 1)、肺一氧化碳弥散量(DLCO)均高于对照组,差异有统计学意义;治疗后,实验组血清白介素-6(IL-6)和C-反应蛋白(CRP)水平均低于对照组,差异有统计学意义;治疗后,实验组生活质量各方面评分均高于对照组;治疗结束后,实验组6min步行距离为(414.56±25.36)m,长于对照组的(405.84±25.68)m,差异有统计学意义;实验组3个月内复发率为11.54%(9/78)低于对照组24.68%(19/77)。结论:信必可持续吸入治疗可降低支气管哮喘患者早晚间咳嗽症状评分,同时改善肺功能指标,提高运动耐力和生活质量评分,降低复发率。Objective To explore the effects of Budesonide and Formoterol Fum arate Powder(Xinbike)continuous inhalation on subjective and objective indexes,exercise tolerance,quality of life and recurrence rate of discharged patients with bronchial asthma.Methods A total of 155 patients with bronchial asthma who were treated in the hospital from November 2015 to December 2019 were enrolled as the research objects.They were divided into control group(77 cases,budesonide inhalation)and experimental group(78 cases,Xinbike continuous inhalation)by random number table method.The scores of clinical symptoms,pulmonary function indexes,levels of serum inflammatory factors,recurrence rate,exercise tolerance and quality of life score before and after treatment were compared between the two groups.Results After treatment,scores of daytime and nighttime cough in experimental group were lower than those in control group.After treatment,vital capacity(VC),forced expiratory volume in one second(FEV 1)and carbon monoxide diffusion capacity(DLCO)in experimental group were higher than those in control group.After treatment,levels of serum interleukin-6(IL-6)and C-reactive protein(CRP)in experimental group are lower than those in control group.After treatment,scores of quality of life from all aspects in experimental group were higher than those in control group.After treatment,the 6-minute walking distance in experimental group was longer than that in control group[(414.56±25.36)m vs(405.84±25.68)m].The recurrence rate within 3 months in experimental group was lower than that in control group[11.54%(9/78)vs 24.68%(19/77)].Conclusion Xinbike continuous inhalation can reduce scores of daytime and nighttime cough in patients with bronchial asthma,improve pulmonary function indexes,improve exercise tolerance and quality of life scores,and reduce recurrence rate.

关 键 词：支气管哮喘 信必可 布地奈德 复发率 运动耐力 

分 类 号：R725.6[医药卫生—儿科]