复方米非司酮联合乳酸依沙吖啶或米索前列醇终止中期妊娠的临床效果  

Clinical effect of compound mifepristone combined with ethacridine lactate or misoprostol on termination of second trimester

作　　者：裴俊俊 PEI Junjun(Yuncheng Maternal and Child Health Hospital,Shanxi Province,Yuncheng 044000,China)

机构地区：[1]山西省运城市妇幼保健院,044000

出　　处：《临床合理用药杂志》2021年第16期27-28,共2页Chinese Journal of Clinical Rational Drug Use

摘　　要：目的比较复方米非司酮分别联合乳酸依沙吖啶、米索前列醇终止中期妊娠的临床效果。方法选择2017年1月-2019年3月于运城市妇幼保健院进行中期妊娠引产的患者120例,采用随机数字表法分为试验组和对照组各60例。试验组给予复方米非司酮连续给药2天,每天1片,36~48 h后行乳酸依沙吖啶100 mg羊膜腔内注射;对照组复方米非司酮给药方式同试验组,36~48 h后阴道放置米索前列醇0.6 mg。比较2组胎儿排出时间、产后出血量、清宫率和引产成功率。结果试验组引产开始至胎儿娩出时间短于对照组,出血量少于对照组(P<0.01);2组清宫率比较差异无统计学意义(χ^(2)=0.120,P=0.729),2组引产成功率均为100.00%。结论复方米非司酮联合阴道放置米索前列醇终止中期妊娠的胎儿排出时间、产后出血均优于复方米非司酮联合乳酸依沙吖啶,但引产成功率和清宫率无显著性差异。Objective To compare the clinical effect of compound mifepristone combined with ethacridine lactate or misoprostol on termination of second trimester.Methods 120 patients who underwent induced labor during the second trimester in Yuncheng Maternal and Child Health Hospital from January 2017 to March 2019 were selected.The patients were randomly divided into experimental group and control group with 60 cases each.In the experimental group,compound mifepristone was administered continuously for 2 days with 1 tablet per day.After 36~48 h,100 mg of ethacridine lactate was injected into the amniotic cavity.The administration of compound mifepristone in the control group was the same as that in the experimental group.Misoprostol was placed 0.6 mg after 36~48 h.The fetal delivery time,postpartum hemorrhage,uterine clearance rate and induced labor success rate were compared between the 2 groups.Results Experimental group induced labor to fetal childbirth time was shorter than the control group,the bleeding was less than the control group(P<0.01).There was no significant difference in the rate of uterine clearance between the two groups(χ^(2)=0.120,P=0.729),the success rate of induced labor in the 2 groups were 100.00%.Conclusion The fetal excretion time and postpartum hemorrhage of compound mifepristone combined with vaginal misoprostol terminated the second trimester are superior to compound mifepristone combined with ethacridine lactate,but there is no significant difference between the success rate of induction of labor and the rate of uterine clearance.

关 键 词：中期妊娠 复方米非司酮 乳酸依沙吖啶 米索前列醇 

分 类 号：R714.2[医药卫生—妇产科学]