开展凝聚胺交叉配血复检在冠心病围术期输血中的临床指导意义分析  

Clinical guiding significance of re-examination of polybrene cross-match test during perioperative blood transfusion for patients with coronary heart disease

作　　者：王苗苗 Wang Miaomiao(Department of Blood Transfusion,Shanxi Provincial Hospital of Cardiovascular Diseases,Taiyuan 030024,China)

机构地区：[1]山西省心血管病医院输血科,太原030024

出　　处：《中国药物与临床》2021年第11期1852-1854,共3页Chinese Remedies & Clinics

摘　　要：目的探究对冠心病围术期输血患者开展凝聚胺交叉配血复检工作的临床指导意义。方法选择我院2019年1月至2020年1月中收治的择期做搭桥手术的冠心病围术期患者180例,只做微柱凝胶法配血作为对照组,开展凝聚胺交叉配血复检作为观察组。对2组的应用效果进行对比。结果在对这180例抗体筛查阴性的患者进行配血时,对照组180例患者中查出3例次侧阳性,占1.7%;观察组180例患者中查出5例次侧阳性,占2.8%。随后重新抽取这5例患者的血液标本,送中心血站进行疑难配血,筛选了和其抗原匹配的血液进行输注,杜绝了输血不良反应的发生。观察组患者的整体不良反应发生率为0.6%,低于对照组的3.9%,差异有统计学意义(P<0.05)。结论在冠心病患者围术期输血过程中开展凝聚胺交叉配血复检工作,可快速检出主次侧血液是否有凝集,减少患者在输血过程中出现的不良反应情况,提升患者的输血治疗效果,方便医生能够快速根据患者实际情况针对性地制定治疗手段,值得在临床上进行推广。Objective To determine the clinical significance of re-examination of polybrene cross-match test during perioperative blood transfusion for patients with coronary heart disease.Methods A total of 180 patients with coronary heart disease,who underwent elective coronary artery bypass grafting during perioperative period between January 2019 and January 2020,were included as the subjects in the study.The patients examined by microcolumn gel cross-match test were included as the control group,and the patients re-examined by polybrene cross-match test were included as the study group.The effects in the two groups were compared.Results After blood matching for the 180 patients with negative antibody,there were 3 of positive secondary side in the control group and 5 of positive secondary side in the study group,accounting for 1.7%and 2.8%,respectively.After that,the blood samples of these five patients were collected again and sent to the central blood station for difficult blood matching.The blood matched with their antigens was screened for transfusion,which prevented the occurrence of adverse reactions of blood transfusion.The overall incidence of adverse reactions in the study group was lower than that in the control group(0.6%and 3.9%),with statistical difference(P<0.05).Conclusion Re-examination of polybrene cross-match test during perioperative blood transfusion for patients with coronary heart disease may detect whether there is agglutination at primary/secondary side rapidly,reduce adverse reactions during blood transfusion,improve the effect of blood transfusion,and favor timely establishment of targeted and individualized treatment,which justifies widespread use in the clinical settings.

关 键 词：凝聚胺交叉配血试验 冠心病 输血检验 

分 类 号：R541.4[医药卫生—心血管疾病] R457.1[医药卫生—内科学]