中国北方地区成年人内脏肥胖相关指标与慢性肾脏病的相关性-基于CHNS数据库研究  

Correlation between visceral obesity and chronic kidney disease in adults in northern China:analysis of CHNS database

作　　者：邵宁[1] 孙治华[1] 柳林伟[1] 金文敏[1] 袁舸[1] 蒋利华 Shao Ning;Sun Zhi-hua;Liu Lin-wei;Jin Wen-min;Yuan Ge;Jiang Li-hua(Department of Nephrology,First Municipal People’s Hospital,Hubei Province,Tianmen 431700,China)

机构地区：[1]湖北省天门市第一人民医院肾内科,431700

出　　处：《临床肾脏病杂志》2021年第6期493-497,共5页Journal Of Clinical Nephrology

摘　　要：目的探讨中国北方地区成年人内脏肥胖相关指标与慢性肾脏病(chronic kidney disease,CKD)的相关性。方法以中国居民健康与营养2009数据库为研究对象,最后有5539人纳入分析。以腰围男性≥90 cm,女性≥85 cm,三酰甘油(triglyceride,TG)≥1.7 mmol/L为切入点,分为正常腰围TG组(A)、高腰围组(B)、高TG组(C)和高TG腰围组(D),同时根据肾小球滤过率(glomerular filtration rate,GFR)分为CKD和非CKD组,计算内脏脂肪指数(vvisceral fat index,VFI)、脂肪蓄积指数(LAP),分析TG腰围分型、VFI、LAP与CKD的相关性。结果D组年龄偏大,血压、腰围、低密度脂蛋白胆固醇(low density lipoprotein cholesterol,LDL-C)、VFI、LAP和体重指数(body mass index,BMI)数值均较其他组高,女性比例、吸烟、饮酒及心肌梗死、高血压、糖尿病、CKD和城市人口所占比重均较其他组高,差异有统计学意义(P<0.05)。CKD组高TG腰围表型组人数较N-CKD高。非条件Logistic回归分析显示,矫正年龄、性别、LDL-C、血压、抽烟、饮酒、高血压、糖尿病、心肌梗死和脑卒中病史等多种因素后,D组较A组患CKD的OR值为1.35(0.98~1.87),有统计学意义。结论高TG腰围表型是北方地区健康成人患CKD较好的预测因子,然而VFI、LAP和BMI与CKD没有相关性。Objective To explore the correlation between visceral obesity and chronic kidney disease(CKD)in adults in northern China.Methods The database of Health and Nutrition of Chinese Residents in 2009 was searched.Finally 5,539 subjects were included for analysis.They were divided into four groups of normal waist triglyceride(TG)(A),high waist circumference(WC)(B),hypertriglyceride(C)and hypertriglyceride WC(D)according to WC≥90 cm in males and 85 cm in females and TG≥1.7 mmol/L.Based upon glomerular filtration rate(GFR),they were divided into CKD and non-CKD groups.Visceral fat index(VAI)and fat accumulation index(LAP)were calculated.And the correlationswere examined between triglyceride waist circumference,VAI,LAP and chronic kidney disease.Results The age of D group was older and blood pressure,waist circumference,LDL-C,VAI,LAP and BMI were higher than other groups.Also proportion of female,smoking,alcoholism,myocardial infarction,hypertension,diabetes,CKD and urban population were higher than other groups(P<0.05).The number of high TG WC phenotype in CKD group was higher than that in non-CKD group.Unconditioned Logistic regression analysis indicated that,after adjusting for age,gender,LDL-C,blood pressure,smoking,alcoholism,hypertension,diabetes,myocardial infarction and stroke history,OR value of D group was 1.35(0.98-1.87).The difference was statistically significant.Conclusion Hypertriglyceride WC phenotype is an excellent predictor of CKD in healthy adults in northern China.However,VAI,LAP or BMI has no correlation with CKD.

关 键 词：慢性肾脏病 三酰甘油 腰围 内脏肥胖 

分 类 号：R692[医药卫生—泌尿科学]