miRs调控巨噬细胞参与慢性肾脏病的研究进展  

Research advances of microRNA regulating macrophages in chronic kidney disease

作　　者：郝相楠 栾军军 周华[1] Hao Xiang-nan;Luan Jun-jun;Zhou Hua(Department of Nephrology,Affiliated Shengjing Hospital,China Medical University,Shenyang 110004,China)

机构地区：[1]中国医科大学附属盛京医院肾内科,沈阳110004

出　　处：《临床肾脏病杂志》2021年第6期515-521,共7页Journal Of Clinical Nephrology

基　　金：国家自然科学基金(81770698,81370835);辽宁省重点研发指导计划(2019JH8/10300009);辽宁省攀登学者(2013222)。

摘　　要：近年来人们不断探索发现,微小RNA(micro RNA,miRs)调节了三分之一的人类基因,在多种疾病的发生、发展中发挥重要作用。慢性肾脏病(chronic kidney disease,CKD)是一种由各种原因引起的持续肾脏结构、功能或二者的持续障碍的临床综合征,肾脏中的巨噬细胞浸润是CKD的共同特征,越来越多的miRs被发现在巨噬细胞执行功能时发挥调控作用,其中一些影响了CKD的发生、发展。It has been recently discovered that microRNA regulates one third of human genes and plays vital roles in the occurrence and development of various diseases.Chronic kidney disease(CKD)is a kind of clinical syndrome of persistent renal structure,function or both caused by various reasons.Macrophage infiltration within kidney is a common feature of CKD.More and more microRNAs assume a regulatory role in macrophage function and affect the occurrence and development of CKD.

关 键 词：微小RNA 巨噬细胞 慢性肾脏病 

分 类 号：R692[医药卫生—泌尿科学]