2-((2-氧代丙基)硒基)-N-(4-乙基苯基)苯甲酰胺的合成、晶体结构及抑癌活性  

Synthesis,Crystal Structure and Anticancer Activity of 2-((2-Oxopropyl)selanyl)-N-(4-ethylphenyl)Benzamide

作　　者：齐凯言 冯书晓[1] 郭亚菲 王俊岭[1] 谷广娜 孙静静 付龙龙 廖源 马军营[1] QI Kai-yan;FENG Shu-xiao;GUO Ya-fei;WANG Jun-ling;GU Guang-na;SUN Jing-jing;FU Long-long;LIAO Yuan;MA Jun-ying(College of Chemical Engineering & Pharmaceutical, Henan University of Science and Technology, Luoyang 471023, China)

机构地区：[1]河南科技大学化工与制药学院,河南洛阳471023

出　　处：《合成化学》2021年第6期503-507,共5页Chinese Journal of Synthetic Chemistry

基　　金：河南省自然科学基金项目资助(182300410353)。

摘　　要：以2-氯硒基苯甲酰氯为原料,合成了2-((2-氧代丙基)硒基)-N-(4-乙基苯基)苯甲酰胺(3),其结构经1H NMR、13C NMR、HR-MS(ESI)和XRD表征。结果表明:3(CCDC:1944723)属单斜晶系,P21/c空间群,晶胞参数为a=18.0933(6),b=9.4337(2)Å,c=9.8684(3)Å,β=91.797(3)°,V=1683.57(8)Å3,Z=4,Dc=1.421 g/cm^(3),F(000)=736.0,R_(gt)(F)=0.0422,wR_(ref)(F2)=0.1145,S=1.028,μ=3.068 mm1。用MTT法测得3(100μg/mL)对食管癌细胞(EC109)的体外增殖抑制率为14.94±0.60%。With 2-chloroselenium-benzoyl chloride as raw material,2-((2-oxopropyl)selanyl)-N-(4-ethylphenyl)benzamide(3)was synthesized.The structure of 3 was characterized by 1H NMR,13C NMR,HR-MS(ESI),and the molecular structure was determined by X-single crystal diffraction.The results showed that 3(CCDC:1944723)belong to monoclinic system,space group P21/c,and the unit cell parameters were a=18.0933(6)Å,b=9.4337(2)Å,c=9.8684(3)Å,β=91.797(3)°,V=1683.57(8)Å3,Z=4,Dc=1.421 g·cm^(-3),F(000)=736.0,R_(gt)(F)=0.0422,wR_(ref)(F2)=0.1145,S=1.028,μ=3.068 mm1.MTT assay showed that the inhibitory rate of 3(100μg/mL)on the proliferation of EC109 cells in vitro was 14.94±0.60%.

关 键 词：2-氯硒基苯甲酰氯 有机硒化合物 合成 晶体结构 抑癌活性 食管癌细胞 

分 类 号：O626[理学—有机化学]