正电子放射性药物自动分装注射系统的设计与测试  

Design and Test of Automatic Dispensing and Injecting System for Positron Radiopharmaceuticals

作　　者：郭宁 王瞳 霍力 李方 刘黎洁[2] 李轶 巴建涛 GUO Ning;WANG Tong;HUO Li;LI Fang;LIU Lijie;LI Yi;BA Jiantao(Department of Nuclear Medicine,PUMC Hospital,CAMS and PUMC,Beijing 100730,China;Department of Nuclear Medicine,Beijing Tongren Hospital,Capital Medical University,Beijing 100730,China)

机构地区：[1]中国医学科学院,北京协和医学院,北京协和医院核医学科核医学分子靶向诊疗北京市重点实验室,北京100730 [2]首都医科大学附属北京同仁医院核医学科,北京100730

出　　处：《中国医学科学院学报》2021年第3期429-434,共6页Acta Academiae Medicinae Sinicae

摘　　要：目的设计研发新型正电子放射性药物自动分装注射系统,以实现精准药物活度注射,简化注射流程,降低职业照射。方法选择钨合金作为屏蔽材料,采用基于单片机控制步进电机驱动技术,设计机械驱动模块、管路系统、控制软件。制作设备及相关配套装置。测量防护效能和性能。结果自动分装注射放射性药物时间约60 s,设备50次稳定性测试空白试验的成功率100%。系统整体注射活度的分装误差≤3%;设备箱体屏蔽40 mmPb,台面屏蔽60 mmPb,隔离防护屏蔽15 mmPb,内置钨合金原液罐50 mmPb。距离运行中设备30 cm处平均剂量率为1.44μSv/h。操作人员肢端辐射剂量较使用注射器防护套注射操作降低99%以上。结论自动分装注射系统操作简便,分装精度高,重复性好,防护安全,达到设计功能和放射防护要求。Objective To design a novel automatic dispensing and injecting system of positron radiopharmaceuticals,for precise dose dispensing,simplified operation,and reduction of occupational radiation exposure.Methods The automatic dispensing and injecting system was fabricated with tungsten alloy as the shielding material.The performance and radiation protection of the device were assessed.Results The total time of injection using the automatic dispensing and injecting system was about 60 s.The ratio of successful injection in stability test was 100%.The deviation of the dispensing dose with the system was≤3%.With the tungsten alloy shield(40 mmPb of the cabinet,60 mmPb of the countertop,15 mmPb of the protective shield,and 50 mmPb of the inbuilt jar for radiopharmaceuticals),the average dose rate at 30 cm from the device was 1.44μSv/h,and the radiation dose at the operator’s extremity was reduced by 99%.Conclusions This automatic dispensing and injecting system of positron radiopharmaceuticals is easy to operate with precise dispensing dose.It is safe and meets the requirements of radiation protection.

关 键 词：正电子放射性药物 步进电机 往复执行器 自动分装 自动注射 

分 类 号：TL8[核科学技术—核技术及应用]