T_(2)WI灰度直方图定量分析在原发性中枢神经系统淋巴瘤和脑胶质瘤鉴别诊断中的价值  

Quantitative Analysis of T_(2)WI Gray Histogram in the Differential Diagnosis of Primary Central Nervous System Lymphoma and Glioma

作　　者：杨婷婷 占鸣[1] 谢春梅 高明 YANG Ting-ting;ZHAN Ming;XIE Chun-mei;GAO Ming(Department of Radiology,Zhejiang Xiaoshan Hospital,Hangzhou 311202,Zhejiang,China)

机构地区：[1]浙江萧山医院放射科,浙江杭州311202

出　　处：《医学信息》2021年第13期4-6,共3页Journal of Medical Information

基　　金：杭州市医药卫生科技项目(编号:B20200234)。

摘　　要：目的探讨T_(2)WI灰度直方图定量分析在原发性中枢神经系统淋巴瘤(PCNSL)和脑胶质瘤鉴别诊断中的价值。方法搜集我院2016年1月-2020年2月经病理证实的14例PCNSL和17例GBM,回顾性分析患者术前MRI资料。在两组T_(2)WI轴位图像的肿瘤最大层面用MaZda软件勾画感兴趣区(ROI)并进行灰度直方图分析,比较两组肿瘤的灰度直方图特征,包括均值(Mean)、变异度(Variance)、偏度(Skewness)、峰度(Kurtosis)、第1百分位数(Perc.1%)、第10百分位数(Perc.10%)、第50百分位数(Perc.50%)、第90百分位数(Perc.90%)、第99百分位数(Perc.99%)。结果通过T_2WI灰度直方图分析得到的9个参数中,变异度、偏度、Perc.90%、Perc.99%四个参数比较,差异有统计学意义(P<0.05);Perc.90%鉴别PCNSL和胶质瘤效能最高,受试者工作特征(ROC)曲线下面积(AUC)为0.962,敏感度和特异度为92.90%、82.40%。结论 T_(2)WI灰度直方图定量分析有助于PCNSL和脑胶质瘤的鉴别,Perc.90%具有较高诊断效能。Objective To explore the value of quantitative analysis of T_(2)WI gray histogram in the differential diagnosis of primary central nervous system lymphoma(PCNSL)and glioma.Methods Collected 14 cases of PCNSL and 17 cases of GBM confirmed by pathology from January 2016 to February 2020 in our hospital,and retrospectively analyzed the preoperative MRI data of the patients.Use MaZda software to delineate the region of interest(ROI)and perform gray-scale histogram analysis on the largest level of the tumor in the two sets of T_(2)WI axial images.Compare the gray histogram features of the two groups of tumors,including mean(Mean),variability(Variance),skewness(Skewness),kurtosis(Kurtosis),1 st percentile(Perc.1%),10 th Percentile(Perc.10%),50 th percentile(Perc.50%),90 th percentile(Perc.90%),99 th percentile(Perc.99%).Results Among the 9 parameters obtained by T_(2)WI gray histogram analysis,the four parameters of variability,skewness,Perc.90%,Perc.99% were compared,the difference was statistically significant(P<0.05);Perc.90%had the highest efficiency in distinguishing PCNSL from glioma,the area under the receiver operating characteristic(ROC)curve(AUC)was 0.962,and the sensitivity and specificity were 92.90% and 82.40%.Conclusion Quantitative analysis of T_(2)WI gray histogram is helpful to distinguish PCNSL from glioma.Perc.90%has a high diagnostic efficiency.

关 键 词：磁共振成像 灰度直方图 原发性中枢神经系统淋巴瘤 脑胶质瘤 

分 类 号：R551.2[医药卫生—血液循环系统疾病]