二维超声及弹性成像预测三阴性乳腺癌新辅助化疗效果的价值  

The Value of Two-dimensional Ultrasound and Elastography in Predicting the Effect of Neoadjuvant Chemotherapy for Triple-negative Breast Cancer

作　　者：杨洁[1] 廖萍[1] 黄志平[1] 黄金长[2] 倪军[3] YANG Jie;LIAO Ping;HUANG Zhi-ping;HUANG Jin-chang;NI Jun(Department of Ultrasound,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China;Department of Pathology,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China;Department of Thyroid and Breast Surgery,Ganzhou People's Hospital,Ganzhou 341000,Jiangxi,China)

机构地区：[1]赣州市人民医院超声科,江西赣州341000 [2]赣州市人民医院病理科,江西赣州341000 [3]赣州市人民医院甲状腺乳腺外科,江西赣州341000

出　　处：《医学信息》2021年第13期173-175,共3页Journal of Medical Information

基　　金：江西省卫生健康委科技计划立项课题(编号:20157188)。

摘　　要：目的探讨二维超声与弹性成像评估三阴性乳腺癌新辅助化疗的预后价值与意义。方法选取我院2012年7月-2020年10月收治的Ⅱ-Ⅲ期三阴性乳腺癌患者32例,分别行二维超声(灰阶+彩色多普勒血流)与弹性成像检查,记录化疗前后病灶基线最长径总和、血流信号、弹性评分及弹性应变比,分析其与患者3、5年总生存率、无瘤生存率及复发与转移的相关性。结果化疗后病灶基线最长径总和评价有效的患者3、5年总生存率、无瘤生存率均高于无效患者(P<0.05);弹性应变比值增高的患者3、5年总生存率、无瘤生存率高于降低患者(P<0.05);不同血流信号和弹性评分的患者3、5年总生存率、无瘤生存率基本一致(P>0.05);不同弹性应变比的患者复发或转移率接近(P<0.05);不同病灶基线最长径总和、血流信号及弹性评分的患者复发或转移率差异不大(P>0.05)。结论二维超声与弹性成像可有效预测三阴性乳腺癌患者新辅助化疗的效果,可为临床制定患者的治疗方案及预后判断提供参考。Objective To explore the prognostic value and significance of two-dimensional ultrasound and elastography in evaluating neoadjuvant chemotherapy for triple-negative breast cancer.Methods A total of 32 patients with stageⅡ-Ⅲtriple-negative breast cancer who were admitted to our hospital from July 2012 to October 2020 were selected for two-dimensional ultrasound(gray scale+color Doppler blood flow)and elastography.The baseline longest diameter sum,blood flow signal,elasticity score,and elastic strain ratio of the lesion before and after chemotherapy were recorded,and the correlation with the 3,5-year overall survival rate,tumor-free survival rate,recurrence and metastasis was analyzed.Results After chemotherapy,the 3,5-year overall survival rate and tumor-free survival rate of patients with effective baseline assessment of the sum of the longest diameter of the lesion were higher than those of ineffective patients(P<0.05);The 3,5-year overall survival rate and tumor-free survival rate of patients with increased elastic strain ratio were higher than those with decreased patients(P<0.05);There was no statistically significant difference in the 3,5-year overall survival rate and tumor-free survival rate of patients with different blood flow signals and elasticity scores(P>0.05);The recurrence or metastasis rate of patients with different elastic strain ratios was compared,the difference was statistically significant(P<0.05);There was no statistically significant difference in the recurrence or metastasis rate of patients with different baseline longest diameter sum,blood flow signal and elasticity score(P>0.05).Conclusion Two-dimensional ultrasound and elastography can effectively predict the effect of neoadjuvant chemotherapy in patients with triple-negative breast cancer,and can provide references for clinical treatment plans and prognostic judgments.

关 键 词：三阴性乳腺癌 新辅助化疗 二维超声 弹性成像 

分 类 号：R445.1[医药卫生—影像医学与核医学]