台湾狗牙花的生物碱类化学成分  

Alkaloids of Ervatamia pandacaqui

作　　者：谢静 范春林[1,2] 徐杰[1,2] 张建 叶文才[1,2,3] 张晓琦[1,2,3] XIE Jing;FAN Chunlin;XU Jie;ZHANG Jian;YE Wencai;ZHANG Xiaoqi(Institute of Traditional Chinese Medicine&Natural Products,College of Pharmacy,Ji'nan University,Guangzhou 510632;Guangdong Engineering Research Center for Modernization of TCM,Ji'nan University,Guangzhou 510632;NMPA Key Laboratory for Quality Evaluation of TCM(Traditional Chinese Patent Medicine),Guangzhou 510632,China)

机构地区：[1]暨南大学药学院中药及天然药物研究所,广州510632 [2]暨南大学广东省现代中药工程技术研究中心,广州510632 [3]国家药品监督管理局中成药质量评价重点实验室,广州510632

出　　处：《中国药科大学学报》2021年第3期287-292,共6页Journal of China Pharmaceutical University

基　　金：国家自然科学基金资助项目(No.U1801287,No.82073712);广东省科技计划资助项目(No.2018B020207008,No.2020B1111110004)。

摘　　要：采用硅胶、Sephadex LH-20、ODS、HPLC等色谱方法进行分离纯化,从夹竹桃科植物台湾狗牙花(Ervatamia pandacaqui Pichon)枝叶中分离得到11个生物碱类化合物,根据其理化性质与波谱数据分别鉴定为voacristine 7-hydroxyindolenine(1),iboxygaine(2),19S-hydroxyibogamine(3),3-oxotabersonine(4),派利文碱(perivine,5),佩西立文(pericyclivine,6),rhazinalinol(7),geissoschizol(8),3,14-dihydroolivacine(9),瓦莱萨明碱(vallesamine,10),conolobine A(11)。化合物1~11均为首次从该植物中分离得到。Eleven alkaloids were isolated from the twigs and leaves of Ervatamia pandacaqui using chromatographic methods of silica gel,Sephadex LH-20,ODS,and HPLC.Their structures were elucidated by physical,chemical and spectroscopic methods and determined as voacristine 7-hydroxyindolenine(1),iboxygaine(2),19S-hydroxyibogamine(3),3-oxotabersonine(4),perivine(5),pericyclivine(6),rhazinalinol(7),geissoschizol(8),3,14-dihydroolivacine(9),vallesamine(10),and conolobine A(11),respectively.All compounds were isolated from this plant for the first time.

关 键 词：夹竹桃科 台湾狗牙花 生物碱 化学成分 分离鉴定 

分 类 号：R284.1[医药卫生—中药学]