瑞马唑仑-丙泊酚-舒芬太尼用于无痛胃镜检查术患者麻醉的效果  

Efficacy of remimazolam-propofol-sufentanil for anesthesia in patients undergoing painless gastroscopy

作　　者：肖兴鹏[1] 郭明[1] 马岚[1] 李思琦 何旋[1] 肖业达[1] 夏中元[1] Xiao Xingpeng;Guo Ming;Ma Lan;Li Siqi;He Xuan;Xiao Yeda;Xia Zhongyuan(Department of Anesthesiology,Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院麻醉科,430060

出　　处：《中华麻醉学杂志》2021年第2期192-194,共3页Chinese Journal of Anesthesiology

摘　　要：目的评价瑞马唑仑-丙泊酚-舒芬太尼用于无痛胃镜检查术患者麻醉的效果。方法拟行无痛胃镜检查术患者80例,年龄20~59岁,体重44~69 kg,ASA分级Ⅰ或Ⅱ级。采用随机数字表法分为2组(n=40):瑞马唑仑-丙泊酚-舒芬太尼组(RPS组)和丙泊酚-舒芬太尼组(PS组)。RPS组患者依次静脉注射舒芬太尼0.1μg/kg、瑞马唑仑0.15 mg/kg和丙泊酚(注射速率4 mg/s);PS组患者静脉注射舒芬太尼0.1μg/kg和丙泊酚(注射速率4 mg/s),待患者OAA/S评分为0时行胃镜检查术。记录丙泊酚用量、麻醉时间、胃镜检查时间、苏醒时间和离院时间,观察术中辅助呼吸例数、体动反应及离院时不良反应的发生情况。结果与PS组比较,RPS组患者丙泊酚用量减少,麻醉时间、苏醒时间和离院时间缩短(P<0.05)。2组患者胃镜检查时间、术中辅助呼吸例数、体动反应及离院时不良反应发生率比较差异无统计学意义(P>0.05)。结论瑞马唑仑-丙泊酚-舒芬太尼用于无痛胃镜检查术患者麻醉的效果优于丙泊酚-舒芬太尼。Objective To evaluate the efficacy of remimazolam-propofol-sufentanil for anesthesia in patients undergoing painless gastroscopy.Methods Eighty American Society of Anesthesiologists physical statusⅠorⅡpatients,aged 20-59 yr,weighing 44-69 kg,scheduled for elective painless gastroscopy,were divided into 2 groups(n=40 each)using a random number table method:remimazolam-propofol-sufentanil group(group RPS)and propofol-sufentanil group(group PS).The patients in group RPS received successive intravenous injection of sufentanil 0.1μg/kg,remimazolam 0.15 mg/kg and propofol(at a rate of 4 mg/s).The patients in group PS received intravenous injection of sufentanil 0.1μg/kg and propofol(at a rate of 4 mg/s).When Observer′s Assessment of Alertness/Sedation Scale score was 0,gastroscopy was performed.The consumption of propofol,time of anesthesia,time for gastroscopy,emergence time and discharge time were recorded.The number of intraoperative assisted respiration cases,body movement and occurrence of adverse reactions at the time of discharge were observed.Results Compared with group PS,the consumption of propofol was significantly decreased,and the time of anesthesia,emergence time and discharge time were shortened in group RPS(P<0.05).There was no significant difference in the time for gastroscopy,the number of intraoperative assisted respiration cases,body movement and the occurrence of adverse reactions at discharge time between the 2 groups(P>0.05).Conclusion Remimazolam-propofol-sufentanil produces better efficacy for anesthesia than propofol-sufentanil in patients undergoing painless gastroscopy.

关 键 词：苯二氮类 二异丙酚 舒芬太尼 胃镜检查 

分 类 号：R614[医药卫生—麻醉学]