左氧氟沙星注射液联合射麻口服液治疗支气管扩张合并感染40例疗效观察  

Therapeutic Effect of Levofloxacin Injection Combined with Shema Oral Liquid on 40 Cases of Bronchiectasis Complicated with Infection

作　　者：程瑞明[1] CHENG Ruiming(The First People's Hospital of Jiujiang,Jiujiang Jiangxi 332000,China)

机构地区：[1]九江市第一人民医院,江西九江332000

出　　处：《药品评价》2021年第9期570-573,共4页Drug Evaluation

摘　　要：目的:观察左氧氟沙星注射液联合射麻口服液治疗支气管扩张合并感染的疗效观察。方法:回顾性选取九江市第一人民医院2019年11月至2020年10月收治的80例支气管扩张合并感染患者资料进行研究,按照治疗方案的不同将其分为对照组(给予常规治疗与左氧氟沙星注射液)与观察组(在对照组基础上联合射麻口服液),每组40例;对比分析两组总有效率、治疗前后的炎症因子水平、症状缓解时间以及不良反应发生率。结果:治疗后14 d,观察组与对照组白细胞介素-6(IL-6)、白细胞介素-8(IL-8)、C反应蛋白(CRP)水平均有所降低,但观察组明显更低(P<0.05);观察组咳嗽缓解时间、咳痰缓解时间、喘息缓解时间、发热缓解时间均短于对照组(P<0.05);观察组总有效率为95.00%,高于对照组的80.00%(P<0.05);观察组、对照组不良反应发生分别为15.00%、17.50%,两组对比差异无统计学意义(P>0.05)。结论:左氧氟沙星注射液联合射麻口服液在支气管扩张患者治疗中有较好的效果,该治疗方案可有效减轻其机体炎症程度,缓解其临床症状,促进病情好转,且安全性高。Objective:To observe the curative effect of levofloxacin injection combined with Shema oral liquid in the treatment of bronchiectasis complicated with infection.Methods:Data of 80 patients with bronchiectasis complicated with infection admitted to The First People's Hospital of Jiujiang from November 2019 to October 2020 were retrospectively selected.According to different treatment regimens,they were divided into control group(given conventional treatment and levofloxacin injection)and observation group(combined with Shema oral solution on the basis of control group),with 40 cases in each group.The total effective rate,the level of inflammatory factors before and after treatment,the time of symptom remission and the incidence of adverse reactions between the two groups were compared and analyzed.Results:14 days after treatment,the levels of interleukin-6(IL-6),interleukin-8(IL-8)and C-reactive protein(CRP)in observation group and control group were decreased,but significantly lower in observation group(P<0.05).The cough relief time,sputum relief time,wheezing relief time and fever relief time in observation group were all shorter than those in control group(P<0.05).The total effective rate of observation group was 95.00%,which was higher than that of control group(80.00%,P<0.05).The incidence of ADR in the observation group and the control group was 15.00%and 17.50%,there was no statistical significance between the two groups(P>0.05).Conclusion:Levofloxacin injection combined with Shema oral solution has a good effect in the treatment of patients with bronchiectasis.This treatment scheme can effectively reduce the degree of inflammation in the body,relieve the clinical symptoms and promote the improvement of the condition,with high safety.

关 键 词：支气管扩张症 左氧氟沙星 射麻口服液 白细胞介素6 C反应蛋白质 临床疗效 

分 类 号：R562.22[医药卫生—呼吸系统]