纳米多孔抗菌纤维的制备及其纺丝工艺的优化  

Preparation and spinning process optimization of antibacterial fibers with the nanoporous structure

作　　者：刀家普 冯焱 曾建 王煜丹 袁明伟[1] DAO Jia-pu;FENG Yan;ZENG Jian;WANG Yu-dan;YUAN Ming-wei(National and Local Joint Engineering Research Center for Green Preparation Technology of Biobased Materials,Yunnan Minzu University,Kunming 650500,China)

机构地区：[1]云南民族大学,生物基材料绿色制备技术国家地方联合工程研究中心,云南昆明650500

出　　处：《云南民族大学学报（自然科学版）》2021年第4期334-342,354,共10页Journal of Yunnan Minzu University:Natural Sciences Edition

基　　金：中国博士后科学基金第67批面上资助(2020M673586XB);云南民族大学民族药资源化学国家民族事务委员会-教育部重点实验室开放基金申请书(2020MZY05).

摘　　要：以高活性二氧化硅铝载银和聚六亚甲基双胍盐酸盐(PHMB)为复合抗菌剂,与聚乳酸(PLA)共混配制不同体系的纺丝液;采用静电纺丝技术制备出具有纳米多孔结构的抗菌纤维材料.通过调控纺丝参数:纺丝液性质、浓度、电压、接收距离、溶剂比例、温度、湿度和抗菌剂添加量,对制备的纤维直径、孔洞覆盖率进行计算,以优化纺丝工艺.结果表明:纺丝液质量百分数7%、电压10.5 kV、接收距离20 cm、DCM/DMF=11∶1、温度25℃、湿度65%、添加4%的复合抗菌剂所制备的纤维直径较为均匀(平均直径947.9 nm),且孔洞覆盖率较高(为52.8%).This research adopts the high-activity silicon dioxide aluminum silver and polyhexamethylformin hydrochloride(PHMB)as a compound antibacterial agent,and obtains polylactic acid(PLA)blend of different systems of spinning solution.The antimicrobial fibers with the nanoporous structure are prepared by electrospinning technique.By adjusting the spinning parameters,such as spinning liquid properties,concentration,voltage,receiving distance,solvent proportion,temperature,humidity and antibacterial-agent amount,the diameter and hole coverage rate of the prepared fiber are calculated to optimize the spinning process.The results have showed that the fibers prepared with the spinning fluid concentration of 7%,the voltage of 10.5 kV,the receiving distance of 20cm,DCM/DMF=11∶1,the temperature of 25℃,the humidity of 65%,and 4%compound antibacterial agent have a uniform diameter(average diameter 947.9 nm)and a high hole-coverage(52.8%).

关 键 词：复合抗菌剂 静电纺丝 多孔结构 抗菌纤维 

分 类 号：TQ340.64[化学工程—化纤工业]