麦角甾苷的神经保护作用研究进展  

Current advances in understanding neuroprotective effectof acteoside in neurodegenerative disease

作　　者：郝丹丹 张垒 张凤宁 白春英 斯日古楞 瑞云 郎卫红 杜冠华[4] 王洪权 HAO Dan-dan;ZHANG Lei;ZHANG Feng-ning;BAI Chun-ying;Siriguleng;RUI Yun;LANG Wei-hong;DU Guan-hua;WANG Hong-quan(Dept of Physiology, Medical college;Dept of Neurosurgery, Affiliated Hospital;Dept of Psychological Medicine, Affiliated Hospital, Chifeng University, Chifeng, Inner Mongolia 024005, China;Institute of Materia Medica, CAMS/PUMC, Beijing 100050, China;Dept of Neurology, Aerospace Center Hospital, Peking University Aerospace School of Clinical Medicine, Beijing 100049, China)

机构地区：[1]赤峰学院基础医学院生理学教研室,内蒙古赤峰024005 [2]赤峰学院附属医院神经外科,内蒙古赤峰024005 [3]赤峰学院附属医院心理医学科,内蒙古赤峰024005 [4]中国医学科学院、北京协和医学院药物研究所,北京100050 [5]航天中心医院、北京大学航天临床医学院神经内科,北京100049

出　　处：《中国药理学通报》2021年第7期906-910,共5页Chinese Pharmacological Bulletin

基　　金：国家自然科学基金项目(No 81260196,81450036);内蒙古自然科学基金项目(No 2018MS08046,2016BS0804,2020MS09715);内蒙古自治区高等学校青年科技英才支持计划(No NJYT-17-B23);“草原英才”工程计划;内蒙古人类遗传病研究重点实验室项目。

摘　　要：麦角甾苷(Acteoside)是一种广泛存在于植物中糖苷类化合物,具有许多药理学活性。最近研究显示,麦角甾苷具有神经保护活性,在神经退行性疾病中的神经保护作用取得了一定进展,该文对麦角甾苷在神经退行性疾病和其他神经系统疾病中的运用基础研究及其可能的神经保护作用机制进行了总结和归纳。总结了麦角甾苷在动物中的药代动力学、临床应用、局限性和将来的应用趋势。Acteoside is among the most widespread of thedisaccharide caffeoyl esters that are widely distributed in the plant kingdom with diverse biological activities.Recent studies have shown that acteoside has neuroprotective activity in neurodegenerative diseases.This review examines and extrapolates from the recent literature to build support for the use of acteoside in mitigating neuropathy in neurodegenerative disease,including Parkinson’s disease(PD)and Alzheimer’s disease(AD).We summarize the main pharmacokinetic parameters of acteoside in animals after different administration routes.Meanwhile,we point out both problems and shortcomings,and highlight its future development trend.

关 键 词：麦角甾苷 神经退行性疾病 阿尔茨海默病 帕金森病 神经保护 

分 类 号：R284.1[医药卫生—中药学] R742.5[医药卫生—中医学]