肿瘤相关巨噬细胞靶向治疗宫颈癌研究进展  

Research progress of targeted therapy for cervical cancer by tumor-associated macrophages

作　　者：陆杭铖 魏炜炜 陈继明[1] 施如霞[1] LU Hangcheng;WEI Weiwei;CHEN Jiming;SHI Ruxia(Department of Gynecology,The Second People′s Hospital of Changzhou City Affiliated to Nanjing Medical University,Changzhou,Jiangsu,213000)

机构地区：[1]南京医科大学附属常州市第二人民医院妇科,江苏常州213000

出　　处：《实用临床医药杂志》2021年第7期123-127,132,共6页Journal of Clinical Medicine in Practice

基　　金：江苏省常州市科技计划资助项目(QN201931)。

摘　　要：肿瘤相关巨噬细胞(TAMs)是肿瘤微环境(TME)中重要的免疫细胞,可分泌多种细胞因子参与和调控宫颈癌(CC)的生物学行为。详细了解TAM影响CC的生长和转移机制,是研发靶向治疗药物的关键。本文就近年来对TAM在CC中的治疗进展进行综述,重点探讨TAM靶向治疗CC的潜在治疗靶点、疫苗及药物,为CC新型靶向药物的研发提供理论依据,以期改善患者生存质量和延长其生存时间。Tumor associated macrophages(TAM)are important immune cells in the tumor microenvironment(TME),which can secrete a variety of cytokines to participate in and regulate the biological behavior of cervical cancer(CC).A detailed understanding of the mechanism of TAM affecting the growth and metastasis of CC is the key to the development of targeted therapies.In this paper,the progress of TAM treatment in CC was reviewed in recent years,and the potential therapeutic targets,vaccines and drugs for TAM targeted treatment of CC were mainly discussed,which may provide theoretical basis for the research and development of novel targeted drugs for CC,in order to improve the quality of life and prolong the survival time of patients.

关 键 词：宫颈癌 肿瘤相关巨噬细胞 免疫治疗 表型转化 疫苗 

分 类 号：R392.3[医药卫生—免疫学] R737.33[医药卫生—基础医学]