产妇孕中期检测血清AFP筛查胎儿神经管缺陷的价值评价  

Evaluation of the value of maternal serum AFP in prenatal screening for fetal neural tube defects in the second trimester

作　　者：王永栋 刘彦强 王莹 王彦广 孙智勇 李珊 李跃晨 WANG Yongdong;LIU Yanqiang;WANG Ying(Ningjin County Hospital,Hebei,Ningjin 055550,China)

机构地区：[1]河北省宁晋县医院,055550

出　　处：《河北医药》2021年第12期1898-1900,共3页Hebei Medical Journal

摘　　要：目的分析孕中期母血清AFP(血清甲胎蛋白)检测产前筛查胎儿神经管缺陷(NTD)的临床应用效果。方法采用回顾性分析,收集2012年1月至2018年12月进行产前筛查的产妇395112例作为研究对象,对上述研究对象的各种资本资料、缺陷监测资料、产前检测结果、随访结果等进行统计分析,利用软件评估胎儿NTD发生风险以及检查准确率。结果在2012年至2018年我县共进行产前筛查患者395112例,其中NTD高风险检出1848例,检出率为0.47%;产妇筛查后对产妇分娩情况等进行随访,395112筛查患者共随访380663例,随访率为96.34%;1848例高风险产妇中检出无脑儿11例、脊柱裂36例、脑膨出9例、NTD 91例,检出率分别为0.60%、1.95%、0.49%、4.92%;378815例低风险产妇中检出无脑儿10例、脊柱裂26例、脑膨出14例、NTD 50例,检出率分别为0.03%、0.07%、0.04%、0.13%,高风险NTD检出率明显高于低风险,差异具有统计学意义(P<0.05)。结论在产妇孕中期进行血清AFP检测产前筛查能够帮助医护人员明确胎儿是否正常,能够有效检出神经管缺陷症,对于提高新生儿出生质量具有较好的应用效果。Objective To investigate the clinical application effects of maternal serum AFP(serum alpha-fetoprotein)in prenatal screening for fetal neural tube defects(NTD)in the second trimester.Methods A retrospective analysis was performed on 395,112 pregnant women who underwent prenatal screening in our hospital from January 2012 to December 2018 who were enrolled as the research subjects.Various general data,defect monitoring data,prenatal testing results,and follow-up results of the above research subjects were collected for statistical analysis,and the risk of fetal NTD and the accuracy rate of the examination were assessed using software.Results A total of 395,112 patients underwent prenatal screening in our city from 2012 to 2018,of whom,1,848 patients at high risk for NTD were detected,with a detection rate being 0.47%.After maternal screening,the delivery status of the mother was followed up.Of 395,112 patients undergoing screening,380,663 patients were followed up,with a follow-up rate being 96.34%.Among 1848 the parturients with high-risk,11 cases of anencephaly,36 cases of spina bifida,9 cases of encephalocele,and 91 cases of NTD were detected,and the detection rates were 0.60%,1.95%,0.49%,and 4.92%,respectively.In addition,10 cases of anencephaly,26 cases of spina bifida,14 cases of encephalocele,and 50 cases of NTD were detected among 378,815 low-risk parturients,and the detection rate was 0.03%,0.07%,0.04%,and 0.13%,respectively.The detection rate of NTD in parturients with high-risk was significantly higher than that in parturients with low-risk(P<0.05).Conclusion The detection of serum AFP in prenatal screening in the second trimester of pregnancy can help medical staff to determine whether the fetus is normal,and can effectively detect neural tube defects,which has a good application effect on improving the quality of newborns.

关 键 词：产前筛查 血清甲胎蛋白 神经管缺陷 

分 类 号：R714.5[医药卫生—妇产科学]