胆固醇电化学生物传感器的研究与进展  

Research and development of electrochemical biosensor for cholesterol

作　　者：范佳琳 王新宇 陈雪 任志宇[2] 潘凯[2] 张谦[3] 张玲 FAN Jialin;WANG Xinyu;CHEN Xue;REN Zhiyu;PAN Kai;ZHANG Qian;ZHANG Ling(College of Chemistry and Chemical Engineering,Shenyang Normal University,Shenyang 110034;College of Chemistry and Materials Science,Heilongjiang University,Harbin 150080;College of Chemistry,Liaoning University,Shenyang 110036)

机构地区：[1]沈阳师范大学化学化工学院,沈阳110034 [2]黑龙江大学化工与材料学院,哈尔滨150080 [3]辽宁大学化学院,沈阳110036

出　　处：《分析试验室》2021年第6期736-744,共9页Chinese Journal of Analysis Laboratory

基　　金：沈阳师范大学校级大学生创新创业训练计划资助项目(x0202010166064);辽宁省教育厅高等学校基本科研项目(LFW201706);辽宁省高等学校创新人才支持计划基金项目(LR2019029)资助。

摘　　要：胆固醇作为一些疾病的重要生物标志物,开发准确且快速的胆固醇检测技术在生物医学应用中具有重要意义。电化学生物传感技术具有检测速度快、灵敏度高、操作方便等优点,成为研制新型高性能胆固醇传感器的主要研究方向。近年来,材料合成技术的提高,新型材料种类的丰富,促进了胆固醇电化学生物传感器在脑和心脏血管疾病临床分析中蓬勃发展。本文以材料为主线,综述了近年来利用导电聚合物、金属及其氧化物纳米材料、碳纳米材料和其他复合功能材料为电极修饰材料,以胆固醇氧化酶为固载酶设计的胆固醇电化学生物传感器的最新进展。Cholesterol is a crucial biomarker for several diseases.Determination of cholesterol is of great importance in clinical analysis because the concentration of blood cholesterol is one of the major parameters for the diagnosis of a number of disorders such as cardiovascular disease,heart disease,stroke,peripheral artery disease,type II diabetes and hypertension.Electrochemical biosensors possess multiple benefits like fast response,ease-to-use and high selectivity,which attracts main interest for making new sensors of cholesterol with high performance.In recent years,the improvement of material synthesis technology and the enrichment of new materials have promoted the vigorous development of cholesterol electrochemical biosensors in clinical analysis of brain and cardiovascular diseases.Taking materials as the main line,this review aims to highlight the recent advances in conductive polymers,metals and the metal oxide nanomaterials,carbon nanomaterials and other functional composite materials for cholesterol biosensor design and construction.

关 键 词：胆固醇 胆固醇氧化酶 电化学 生物传感器 纳米材料 修饰电极 

分 类 号：O657.1[理学—分析化学] O646[理学—化学]