线粒体相关蛋白与股骨头坏死关联性研究进展  

Research progress on the correlation between mitochondrial related protein and osteonecrosis of the femoral head

作　　者：乌日莎娜 何伟 魏秋实[2,3] WU Ri-Sha-Na;HE Wei;WEI Qiu-Shi(Third School of Clinic Medicine,Guangzhou University of Chinese Medicine,Guangzhou 510407,China;Department of Joint Orthopaedics,the Third Affiliated Hospital of Guangzhou University of Chinese Medicine,Guangzhou 510240,China;Institute of Orthopaedics of Guangzhou University of Chinese Medicine,Guangzhou 510240,China)

机构地区：[1]广州中医药大学第三临床医学院,广州510407 [2]广州中医药大学第三附属医院关节骨科,广州510240 [3]广州中医药大学骨伤科研究所,广州510240

出　　处：《生命科学》2021年第4期518-526,共9页Chinese Bulletin of Life Sciences

基　　金：国家自然科学基金面上项目(81904226,8187-3327);广东省自然科学基金项目(2017A030313698)。

摘　　要：骨组织细胞凋亡和自噬学说越来越被认同,逐渐成为人们研究股骨头坏死发病机制的焦点。在刺激因素作用后,线粒体功能障碍,影响自噬,诱发骨组织细胞凋亡,最终导致股骨头坏死的发生和发展。这一关联的发现对进一步阐明本病的发病机制具有重要意义,同时检测线粒体相关蛋白可能对股骨头坏死早期诊断和预后判断有较高的参考价值,也为未来调控相关蛋白表达进而影响股骨头坏死进展提供理论依据。The theory of apoptosis and autophagy in bone tissue has been recognized by more and more people and has gradually become the focus of research on pathogenesis of osteonecrosis of the femoral head(ONFH). After the action of stimulating factors, mitochondrial dysfunction induces autophagy and apoptosis of bone tissue cells, and eventually leads to the development and progression of ONFH. The discovery of correlation is of great significance to elucidate the pathogenesis of ONFH. Meanwhile, detection of mitochondrial related proteins may play an important role in early diagnosis and prognosis of ONFH. It also provides theoretical basis for regulating the expression of related proteins to affect progress of ONFH in the future.

关 键 词：线粒体功能障碍 细胞凋亡 自噬 线粒体相关蛋白 股骨头坏死 

分 类 号：R681[医药卫生—骨科学]