A novel ITAM-containing immunoglobulin superfamily receptor involved in lamprey VLRB+lymphocyte immune response  

作　　者：Xin Liu Sifan Wang Qidi Ma Wenjing Liang Jun Li Ting Zhu Qingwei Li Yinglun Han 

机构地区：[1]Lamprey Research Center,College of Life Science,Liaoning Normal University,Dalian 116081,China [2]Collaborative Innovation Center of Seafood Deep Processing,Dalian Polytechnic University,Dalian 116034,China [3]Fujin No.1 Middle School of Heilongjiang,Fujin 156100,China

出　　处：《Acta Biochimica et Biophysica Sinica》2021年第6期800-803,共4页生物化学与生物物理学报（英文版）

基　　金：supported by the grants from the National Natural Science Foundation of China(No.31801973);the Scientific Research Foundation of the Higher Education Institutions of Liaoning Province,China(No.LZ201783601);Liaoning Marine Fisheries Department Project(No.201809);National Natural Science Foundation of Liaoning Province,China(No.2020-MS-245)。

摘　　要：Adaptive immunity is a specific response of lymphocytes under the stimulation of pathogens,which plays a key role in eliminating pathogens and can produce immune memory effect in preventing reinfection[1].The specificity of the immune response in higher vertebrates is based on the huge antigen receptor spectrum composed of major histocompatibility complex(MHC),T cell receptor(TCR),and B cell receptor(BCR)[2].Although the jawless vertebrates lack the typical immune receptors such as TCR,BCR,and MHC,another type of adaptive immune system formed by other ways has been found[3].Pancer et al.[4]found three types of variable lymphocyte receptor(VLR)in the sea lamprey(Petromyzon marinus).The structural diversity of VLRs results in the diversity and combination of many leucine-rich repeat modules so that each lymphocyte produces only one receptor molecule with a specific structure for a specific antigen[5].VLRA and VLRC are found to be similar toαβandγδT cells of higher vertebrates,which are expressed on VLRA+and VLRC+lymphocytes in gills,respectively[6,7].VLRB is specifically expressed on VLRB+cells(accounting for 90%of the total peripheral blood lymphocytes).Its function is similar to B cells of higher vertebrates.It differentiates into plasma-like cells and expresses secretory VLRB tetramer or pentamer antibodies after antigen stimulation[7].

关 键 词：stimulation LYMPHOCYTES immunity 

分 类 号：R392[医药卫生—免疫学]