血清BNP、cTnI水平与急性心肌梗死患者心肌缺血程度的相关性  

Correlation between serum BNP,cTnI levels and degree of myocardial ischemia in patients with acute myocardial infarction

作　　者：陆晨 冯佳佳 何小宇 Lu Chen;Feng Jiajia;He Xiaoyu(Department of Critical Care Medical,Rugao People’s Hospital,Nantong 226560,China)

机构地区：[1]如皋市人民医院重症医学科,南通226560

出　　处：《中华保健医学杂志》2021年第3期221-223,共3页Chinese Journal of Health Care and Medicine

基　　金：南通市市级科技计划项目(MSZ19078)。

摘　　要：目的观察急性心肌梗死(acute myocardial infarction,AMI)患者心肌缺血程度与血清B型脑利钠肽(BNP)、心肌肌钙蛋白(cTnI)水平,并分析血清BNP、cTnI水平与心肌缺血程度之间的相关性。方法回顾性分析如皋市人民医院2017年6月~2019年6月收治的98例急性心肌梗死患者,根据入组患者病历资料Gensini积分将其中轻度狭窄32例患者纳入A组,中度狭窄33例患者纳入B组,重度与极重度狭窄者33例患者纳入C组,对比3组患者血清BNP、cTnI水平,并分析血清BNP、cTnI水平与Gensini积分之间的相关性。结果3组患者年龄、性别等一般资料对比,差异无统计学意义(P>0.05);3组患者心肌缺血总负荷及Gensini积分对比,由高至低依次为C组、B组、A组,差异有统计学意义(P<0.05);A组血清BNP、cTnI水平>B组>C组,差异有统计学意义(P<0.05);双变量Pearson相关性检验,血清BNP、cTnI水平与心肌缺血总负荷积分均呈正相关(r=0.507、0.546,P<0.001)。结论急性心肌梗死患者血清BNP、cTnI水平与心肌缺血程度密切相关,临床可通过检测患者血清BNP、cTnI水平来预测急性心肌梗死患者心肌缺血程度,并据此及时给予干预治疗,旨在提高患者预后。Objective To observe the degree of myocardial ischemia and the levels of serum B-type natriuretic peptide(BNP)and cardiac troponin(cTnI),and to analyze the correlation between serum BNP,cTnI levels and degree of myocardial ischemia,aiming to provide new reference targets for the early diagnosis of patients with acute myocardial infarction.Methods The cluster sampling method was used to retrospective analyze the clinical data of 98 patients with acute myocardial infarction who admitted in the hospital from June 2017 to June 2019.According to the Gensini scores in medical data of selected cases,32 patients with mild stenosis were included in A group,33 patients with moderate stenosis were included in B group,and 33 patients with severe and extremely severe stenosis were included in C group.The levels of serum BNP and cTnI were compared of patients among the three groups,and the correlation between serum BNP,cTnI levels and Gensini score was analyzed.Results There was no statistical significant difference in the general data such as name and gender of patients among the three groups(P>0.05);compared the total myocardial ischemic load and Gensini score of patients among the three groups,in the order from high to low were group C,group B and group A,there was a statistical significant difference(P<0.05);the levels of serum BNP and cTnI in group A were>group B>group C,there was a statistical significant difference(P<0.05);bivariate Pearson correlation test showed that serum BNP and cTnI levels were positively correlated with the total myocardial ischemic load score(r=0.507,0.546,P<0.001).Conclusion The levels of serum BNP and cTnI in patients with acute myocardial infarction are closely related to the degree of myocardial ischemia.Clinically,the degree of myocardial ischemia in patients with acute myocardial infarction can be predicted by detecting the levels of serum BNP and cTnI,and timely intervention treatment should be given accordingly to improve the prognosis of patients.

关 键 词：急性心肌梗死 血清B型脑利钠肽 心肌肌钙蛋白 心肌缺血程度 

分 类 号：R541[医药卫生—心血管疾病]