氨基磺酸催化合成类辣椒碱N-(3,4-二羟基-6-丙烯酰胺甲基苄基)丙烯酰胺  

SYNTHESIS OF CAPSAICIN N-(3,4-DIHYDROXYL-6-ACRYLAMIDE METHYL BENZYL)ACRYLAMIDE CATALYZED BY SULFAMIC ACID

作　　者：岳金方[1] 周月芹 王雪源[1] 罗志臣[1] 雍达明 呙茗婕 侯海超 Yue Jinfang;Zhou Yueqin;Wang Xueyuan;Luo Zhichen;Yong Daming;Guo Mingjie;Hou Haichao(School of Chemical Engineering,Yangzhou Polytechnic Institute,Yangzhou 225127,Jiangsu,China;Chemistry Teaching and Research Office,Jiangbei Machinery Factory Middle School,Jilin 132021,Jilin,China)

机构地区：[1]扬州工业职业技术学院化学工程学院,江苏扬州225127 [2]吉林省吉林市江北机械厂中学化学教研室,吉林吉林132021

出　　处：《精细石油化工》2021年第3期46-49,共4页Speciality Petrochemicals

基　　金：国家自然科学基金青年基金项目(21507021);江苏省自然科学基金面上项目(BK20191220);苏教师〔2019〕3号江苏高校“青蓝工程”优秀教学团队(2019-69);江苏省扬州市市级计划市校合作项目(YZ2019128)。

摘　　要：在无水乙醇溶液中,以邻苯二酚和N-羟甲基丙烯酰胺为原料、氨基磺酸为催化剂合成类辣椒碱N-(3,4-二羟基-6-丙烯酰胺甲基苄基)丙烯酰胺,产物结构经IR和1H NMR表征。考察了原料摩尔比、催化剂用量、反应温度及时间等因素对产品收率的影响。结果表明,氨基磺酸对该反应具有良好的催化活性,较优工艺条件为:邻苯二酚用量11.0 g,n(邻苯二酚)∶n(N-羟甲基丙烯酰胺)=1∶2.25,氨基磺酸用量为邻苯二酚质量的3%,反应温度35℃,反应时间10 d,产物收率大于74%。In anhydrous ethanol solution,N-(3,4-dihydroxy-6-acrylamide benzyl)acrylamide was synthesized from catechol and N-hydroxymethyl acrylamide using sulfamic acid as catalyst.The product was characterized by IR and 1H NMR.The effects of the molar ratio of raw materials,the amount of catalyst,the reaction temperature and time on the yield were investigated.The experimental results showed that sulfamic acid had good catalytic activity for the reaction,and the optimal process conditions were as follows:catechol 11.0 g,n(catechol)∶n(N-hydroxymethylacrylamide)=1∶2.25,the dosage of sulfamic acid was 3%of the mass of catechol,and the reaction was conducted at 35℃for 10 d.Under optimal conditions,the product yield exceeded 74%.

关 键 词：辣椒碱 N-(3 4-二羟基-6-丙烯酰胺甲基苄基)丙烯酰胺 氨基磺酸 合成 

分 类 号：TQ226.3[化学工程—有机化工]