无尾鸡骨骼发育关键信号通路研究进展  

Research Progress on Key Signaling Pathways in Bone Development of Rumpless Chicken

作　　者：齐旺梅[1] 徐斯日古楞 哈登楚日亚 刘斌[2,3] 胡斯乐 孙燕勇 张文广[2] QI Wangmei;XU Siriguleng;HA Dengchuriya;LIU Bin;HU Sile;SUN Yanyong;ZHANG Wenguang(College of Veterinary Medicine,Inner Mongolia Agricultural University,Hohhot 010018,China;College of Animal Sciences,Inner Mongolia Agricultural University,Hohhot010018, China;Inner Mongolia Benniu Science and Technology Co.,Ltd.,Hohhot010020, China;Department of Animal Science and Veterinary, Vocational and Technical College of Inner Mongolia Agricultural University,Baotou 014199,China;College of Life Sciences and Food Engineering,Inner Mongolia University for Nationalities,Tongliao 028000,China)

机构地区：[1]内蒙古农业大学兽医学院,呼和浩特010018 [2]内蒙古农业大学动物科学学院,呼和浩特010018 [3]内蒙古犇牛科技有限公司,呼和浩特010020 [4]内蒙古农业大学职业技术学院畜牧兽医技术系,包头014199 [5]内蒙古民族大学生命科学学院,通辽028000

出　　处：《中国畜牧兽医》2021年第6期2011-2019,共9页China Animal Husbandry & Veterinary Medicine

基　　金：国家自然科学基金(31860640)。

摘　　要：骨骼系统对机体的生命活动至关重要,它为生物体提供了造血微环境、机械支撑、保护脏器等功能,同时也是钙和其他矿物质等的储存库。家鸡尾骨的表型多样性是研究骨骼系统发育及形成机制的良好资源。Notch、Wnt信号通路的靶基因及其相互作用可以形成周期性表达的特点,是调节体节形成及尾部骨骼终止延伸的分子通路。为了解无尾鸡骨骼发育终止的分子机制,作者分别总结了骨骼发育、无尾鸡骨骼研究进展,并重点讨论影响无尾性状的关键信号通路Notch、Wnt及其在无尾鸡研究中的进展。但是,受体和配体之间相互作用的精确调节以及信号通路中的核心元素仍不清楚,需要通过更多的功能基因组和蛋白质组等方法进行深入研究。The skeletal system is crucial to the life activities of the organism,it provides the hematopoietic micro-environment,mechanical support,organ protection and other functions,as well as a reservoir of calcium and other minerals.The phenotypic diversity of chicken tailbone is a good resource for study of skeletal phylogeny and mechanism.To understand the molecular mechanism of skeletal developmental termination in the Rumpless chicken,this paper summarized the development of skeletal,the skeletal research in Rumpless chicken,and focus on the key signaling pathways of Notch and Wnt that influence the characteristics of rumpless and research progress of the Rumpless chicken.Target genes of Notch and Wnt signaling pathways and their interactions can form the characteristic of periodic expression,which is a molecular pathway regulating body segment formation and tailbone extension.However,the precise regulation of the interaction between the receptor and ligand and the core elements in the signaling pathway are still unclear,and more functional genomic and proteomic technology are needed for further study.

关 键 词：无尾鸡 骨骼发育 分子机制 NOTCH信号通路 WNT信号通路 

分 类 号：S831[农业科学—畜牧学]