The role of dendritic cells derived osteoclasts in bone destruction diseases  

作　　者：Bo Wang Yutong Dong Zhansong Tian Yueqi Chen Shiwu Dong 

机构地区：[1]Department of Biomedical Materials Science,Third Military Medical University(Army Medical University),Chongqing,400038,PR China [2]Battalion of Basic Medical Sciences,Third Military Medical University(Army Medical University),Chongqing,400038,PR China [3]Department of Orthopedics,Southwest Hospital,Third Military Medical University(Army Medical University),Chongqing,400038,PR China [4]State Key Laboratory of Trauma,Burns and Combined Injury,Third Military Medical University(Army Medical University),Chongqing,400038,PR China

出　　处：《Genes & Diseases》2021年第4期401-411,共11页基因与疾病（英文）

基　　金：This work was supported by grants from the Key Program of Nature Science Foundation of China(grant number 81930067);the Medical Science and Technology Youth Cultivation Project of PLA China(grant number 20QNPY022);Medical innovation capability upgrading Plan of Southwest Hospital China(grant number SWH2018LJ-03);Medical innovation of graduate students in Chongqing China(grant number CYS19360).

摘　　要：The bone is previously considered as a dominant organ involved in the processes of locomotion.However,in the past two decades,a large number of studies have suggested that the skeletal system closely coordinated with the immune system so as to result in the emerging area of'osteoimmunology'.In the evolution of many kinds of bone destruction-related dis-eases,osteoclasts could differentiate from dendritic cells,which contributed to increased expression of osteoclast-related membrane receptors and relatively higher activity of bone destruction,inducing sewere bone destruction under inflammatory conditions.Numerous fac-tors could influence the interaction between osteoclasts and dendritic cells,contributing to the pathogenesis of several bone diseases in the context of inflammation,including both im-munocytes and a large number of cytokines.In addition,the products of osteoclasts released from bone destruction area serve as important signals for the differentiation and activation of immature dendritic cells.Therefore,the border between the dendritic cell-rela ted immune response and osteoclast-related bone destruction has gradually unravelled.Dendritic cells and osteoclasts cooperate with each other to mediate bone destruction and bone remodelling under inflammatory conditions.In this review,we will pay attention to the interactions be-tween dendritic cells and osteoclasts in physiological and pathological conditions to further understand the skeletal system and identifty potential new therapeutic targets for the future by summarizing their significant roles and molecular mechanisms in bone destruction.

关 键 词：Bone destruction diseases Dendritic cells OSTEOCLASTS OSTEOIMMUNOLOGY TRANS-DIFFERENTIATION 

分 类 号：R329.2[医药卫生—人体解剖和组织胚胎学] R68[医药卫生—基础医学]