SARS-CoV-2 and hearing:An audiometric analysis of COVID-19 hospitalized patients  

作　　者：Francisco Alves de Sousa Rodrigo Pinto Costa Sandra Xará Ana Nóbrega Pinto Cecília Almeida e Sousa 

机构地区：[1]Centro Hospitalar Universitario do Porto,Serviço de Otorrinolaringologia e Cirurgia da Cabeça e Pescoço(Otorhinolaryngology and Head&Neck surgery Department),Largo Prof.Abel Salazar,4099-001,Porto,Portugal [2]Unidade de Saúde Familiar Garcia de Orta,ACeS Porto Ocidental,Medicina Geral e Familiar(Family Medicine),R.Pinho Leal 29,4150-620,Porto,Portugal [3]Centro Hospitalar Universitario do Porto,Serviço de Doenças Infeciosas(Infectious Diseases Department),Largo Prof.Abel Salazar,4099-001,Porto,Portugal

出　　处：《Journal of Otology》2021年第3期158-164,共7页中华耳科学杂志（英文版）

摘　　要：Purpose COVID-19 associated hearing loss is still an ongoing matter of debate.No original studies exist on audiological effects of SARS-CoV-2 infection in hospitalized patients.The main objective was to determine whether SARS-CoV-2 may affect auditory function in clinically ill COVID-19 patients.Materials and methods COVID-19 patients with moderate-severe disease and without prior history of hearing abnormalities were enrolled from a tertiary referral center,and matched with controls.Participants performed an audiometric evaluation,and thresholds were compared.Results 120 ears from 60 patients were enrolled.Patients with COVID-19 showed worse mean auditory thresholds starting from 1000 Hz through higher frequencies,when compared to controls(1000 Hz:18.52±5.49 dB HL in controls vs 25.36±6.79 dB HL in COVID-19,p<0.001;2000Hz:17.50±5.57 dB HL in controls vs 21.96±7.05 dB HL in COVID-19,p=0.010;3000Hz:17.97±8.07 dB HL in controls vs 25±9.38 dB HL in COVID-19,p=0.003;4000 Hz:20.16±10.12 dB HL in controls vs 29.55±11.26 dB HL in COVID-19,p=0.001;8000 Hz:31.09±12.75 dB HL in controls vs 40.71±19.40 dB HL in COVID-19,p=0.030;Pure Tone Average:20.42±4.29 dB HL in controls vs 24.85±5.62 dB HL in COVID-19,p=0.001).Statistical significance persisted after adjusting for confounders such as age,gender and various comorbidities(p<0.05).Conclusions SARS-CoV-2 may affect hearing in COVID-19 patients with moderate-severe disease.Results are in line with the previous suggested effects of COVID-19 on auditory system.This study is expected to encourage further research on this topic.

关 键 词：SARS-CoV-2 COVID-19 CORONAVIRUS AUDIOMETRY HEARING 

分 类 号：R563.1[医药卫生—呼吸系统] R764[医药卫生—内科学]