系统毒理学研究进展  

Advances in systems toxicology research

作　　者：靳远 刘玉真 戚光帅 于典科 JIN Yuan;LIU Yuzhen;QI Guangshuai;YU Dianke(School of Public Health,Qingdao University,Qingdao,Shandong 266073,China)

机构地区：[1]青岛大学公共卫生学院,山东青岛266073

出　　处：《环境与职业医学》2021年第5期447-453,共7页Journal of Environmental and Occupational Medicine

基　　金：国家重点研发计划(2017YFC1600200)。

摘　　要：系统毒理学作为毒理学领域的一门新兴学科,旨在整合生物学多层次信息,从整体解析外源化学物的毒性机制。相较于传统毒理学,它具有独特的优势。本综述介绍了系统毒理学中主要的毒代动力学和毒效动力学的概念,并系统总结了近年来毒效动力学的发展历程和研究进展。《21世纪毒性测试》报告中提出的“毒性通路”为毒性评价体系的发展指明了方向,其与毒作用模式、有害结局路径及其网络一起,成为毒效动力学研究的主要关注点,并为化学物危害识别、毒性测试和风险评估构建了新型框架。目前,有害结局路径仍处在发展的初始阶段,有诸多问题需要进一步研究探索。Systems toxicology is a new branch of science that aims to decode the mechanisms by which external stimuli cause toxic effects from the perspective of body systems.It usually requires integration of information from multiple biological levels to cope with modelling and prediction purposes.In this review,two primary research areas of systems toxicology,toxicokinetics and toxicodynamics,are introduced,and the history and recent progress of the latter are discussed.The Toxicity Testing in the 21st Century:A Vision and a Strategy report called for focus on perturbations of key toxicity pathways to base the future testing platform.Another two pathwaybased approaches,mode of action(MOA)and adverse outcome pathway(AOP),are also main efforts in toxicodynamics and provide a framework for hazard identification,toxicity testing,and human health risk assessment.Attempts in developing AOPs are in the initial stage,and open questions encourage future progress in this field.

关 键 词：系统毒理学 毒性通路 毒作用模式 有害结局路径 风险评估 

分 类 号：R114[医药卫生—卫生毒理学]