细颗粒物暴露与脑卒中发生关联的研究进展  

Research progress on relationship between fine particulate matter exposure and stroke

作　　者：郝佳琪 何兴月 段虎斌[3] 曹慧丽[2] HAO Jiaqi;HE Xingyue;DUAN Hubin;CAO Huili(First Clinical Medical College,Shanxi Medical University,Taiyuan,Shanxi 030001,China;School of Nursing,Shanxi Medical University,Taiyuan,Shanxi 030001,China;Department of Neurosurgery,The First Hospital of Shanxi Medical University,Taiyuan,Shanxi 030001,China)

机构地区：[1]山西医科大学第一临床医学院,山西太原030001 [2]山西医科大学护理学院,山西太原030001 [3]山西医科大学第一医院神经外科,山西太原030001

出　　处：《环境与职业医学》2021年第5期547-552,共6页Journal of Environmental and Occupational Medicine

基　　金：中国博士后基金特别资助项目(2019T120195);山西省卫生健康委科研课题(2019029)。

摘　　要：世界卫生组织将细颗粒物(PM_(2.5))污染列为全球卫生面临的十项威胁之一。近年来,PM_(2.5)污染对脑卒中的影响成为新的关注点。本文综述了PM_(2.5)暴露与脑卒中的流行病学研究;论述了PM_(2.5)暴露可能促发或诱导脑卒中发生发展的生物学新机制,包括PM_(2.5)易位、自主神经功能障碍、糖异生、表观遗传机制等;归纳了PM_(2.5)暴露与脑卒中发生的影响因素;提出建立脑卒中高危人群发病以及患者死亡的预警机制,从而为国内脑卒中一级防控及空气污染治理开展提供借鉴。The World Health Organization lists fine particulate matter(PM_(2.5)) as one of the ten threats to global health. In recent years, the impact of PM_(2.5) pollution on stroke has become a new focus. This article reviewed the epidemiological studies on PM_(2.5) exposure and stroke, and discussed the new biological mechanisms that PM_(2.5) exposure may trigger or induce the occurrence and development of stroke, including PM_(2.5) translocation, autonomic dysfunction, gluconeogenesis, and epigenetic mechanisms. The factors affecting PM_(2.5) exposure and stroke occurrence were summarized. It was proposed to establish an early warning mechanism for the incidence and death of high-risk stroke groups, aiming to provide reference for the primary prevention and control of stroke and air pollution control in China.

关 键 词：细颗粒物 脑卒中 流行病学研究 机制 

分 类 号：R12[医药卫生—环境卫生学]