2型糖尿病患者非空腹血脂检测的临床研究  

Clinical study on non-fasting blood lipids in patients with type 2 diabetes

作　　者：武大伟[1] 刘双庆[1] 宁莉[1] Wu Dawei;Liu Shuangqing;Ning Li(Department of Laboratory Medicine,Second Hospital of Tianjin Medical University,Tianjin 300211,China)

机构地区：[1]天津医科大学第二医院检验科,300211

出　　处：《中华内分泌外科杂志》2021年第3期239-242,共4页Chinese Journal of Endocrine Surgery

基　　金：天津市卫健委应用基础研究基金(2015KZ101)。

摘　　要：目的探讨非空腹血脂检测在2型糖尿病(type 2 diabetes mellitus,T2DM)患者中开展的可行性。方法选取2018年10月至2019月4月在天津医科大学第二医院住院的426名T2DM患者,分别采集患者的空腹和非空腹状态下血液样本,同时测定血浆三酰甘油(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)水平,采用自身对照法进行比较,两次检测的结果采用wilcoxon符号秩检验法进行对比。结果与空腹下检测结果相比,非空腹TG升高0.25 mmol/L(11.2%),差异有统计学意义(P<0.05);TC升高0.17 mmol/L(4.5%),HDL-C升高0.08 mmol/L(5.75%),LDL-C降低0.05 mmol/L(5.9%),差异无统计学意义(P>0.05)。结论除TG外,非空腹TC、HDL-C、LDL-C与空腹状态相比变化微小,可代替空腹血脂检测作为T2DM患者血脂谱的检测方法。Objective To study the feasibility of non-fasting blood lipid detection in patients with type 2 diabetes mellitus(T2DM).Methods A total of 426 diabetic patients hospitalized in the Second Hospital of Tianjin Medical University from Oct.2018 to Apr.2019 were selected to collect blood samples from the fasting and non-fasting state of the patients respectively.The levels of plasma three acylglycerol(TG),total cholesterol(TC),high density lipoprotein cholesterol(HDL-C)and low density lipoprotein cholesterol(LDL-C)were measured at the same time,and self-control method was used.The results of two tests were compared with the wilcoxon signed-rank test.Results Compared with the fasting results,non-fasting TG increased by 0.25 mmol/L(11.2%),with statistical significance(P<0.05);TC increased by 0.17 mmol/L(4.5%),HDL-C increased by 0.08 mmol/L(5.7%),and LDL-C decreased by 0.05 mmol/L(5.9%),without significant differenc(P>0.05).Conclusion Except for TG,non-fasting TC,HDL-C,LDL-C has little change compared with those in fasting state,which can replace fasting blood lipid detection as a method for detecting blood lipid profile in patients with T2DM.

关 键 词：糖尿病 血脂 心血管疾病 非空腹血脂 

分 类 号：R587.1[医药卫生—内分泌]