Traditional Chinese medicine is a useful and promising alternative strategy for treatment of Sjogren’s syndrome:A review  

作　　者：Shu-jun Wei Qing-man He Qing Zhang Kang-hua Fu Ruo-lan Li Wei Peng Yong-xiang Gao 

机构地区：[1]School of Basic Medicine,Chengdu University of Traditional Chinese Medicine,Chengdu 611130,Sichuan Province,China [2]Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 611130,Sichuan Province,China [3]School of Pharmacy,Chengdu University of Traditional Chinese Medicine,Chengdu 611130,Sichuan Province,China [4]International Education College,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,Sichuan Province,China

出　　处：《Journal of Integrative Medicine》2021年第3期191-202,共12页结合医学学报（英文版）

基　　金：supported by the National Science and Technology Major Project of the Ministry of Science and Technology of China(No.2018ZX09721004-009-002);Xinglin Scholar Research Promotion Project of Chengdu University of TCM(No.BSH2018006)。

摘　　要：Primary Sjogren’s syndrome(p SS)is a chronic autoimmune disease involving exocrine glands.Current studies have found that the occurrence of the disease is closely related to genetic,environmental and neuroendocrine factors,as well as abnormal activation of T and B lymphocytes.The etiology and pathogenesis of p SS is complex,and there is a lack of specific targeted drugs.Traditional Chinese medicines(TCMs)have been comprehensively investigated for their treatment effects on p SS.Through a systematic review of the literature,we summarized the TCMs used to treat p SS,and find that there are four major ways that TCMs are used,including upregulation of aquaporin proteins,suppression of cell apoptosis,suppression of the abnormal activation of B lymphocytes and suppression of the abnormal activation of T lymphocytes(balancing T helper type[Th]1/Th 2& Th17/Treg and suppressing follicular helper T[Tfh]cells).However,there are not enough data about the active constituents,quality control,pharmacokinetics,toxicity and modern preparations of these TCMs;therefore,more investigations are needed.This paper highlights the importance of TCMs for treating p SS and provides guidance for future investigations.

关 键 词：Primary Sjogren’s syndrome Autoimmune diseases Traditional Chinese medicine Alternative and complementary medicine 

分 类 号：R259[医药卫生—中西医结合]