白细胞介素36与肺部炎症性疾病的相关性研究  

Relevant study Between Interleukin 36 and Pulmonary Inflammatory Diseases

作　　者：张绍开 李富增 赵佳慧 许媛媛 ZHANG Shaokai;LI Fuzeng;ZHAO Jiahui;XU Yuanyuan(Beijing Changping Hospital Of Chinese Medicine, Beijing 102200;Hu Xishu Research Office Beijing Changping traditional Chinese Medicine Hospital Branch, Beijing 102200, China)

机构地区：[1]北京市昌平区中医医院老年病科,102200 [2]胡希恕名家研究室北京市昌平区中医医院分站,102200

出　　处：《中国老年保健医学》2021年第3期119-121,共3页Chinese Journal of Geriatric Care

基　　金：全国中医药创新骨干人才培训项目(国中医药人教函[2019]128号);北京中医药薪火传承“3+3”工程建设项目——胡希恕名家研究室北京市昌平区中医医院分站(京中医科字[2019]103号)。

摘　　要：白细胞介素36是白细胞介素1家族成员,包括白细胞介素36α、白细胞介素36β、白细胞介素36γ和白细胞介素36受体拮抗剂,其共同受体是白细胞介素36受体。白细胞介素36与白细胞介素1家族具有同源性,可以激活丝裂原激活蛋白激酶、核因子-κB信号通路,参与肺部炎症性疾病的发生和发展过程。现对白细胞介素36的命名、生物学特点、受体与信号通路、与肺部炎症性疾病的关系及应用前景进行综述。Interleukin 36,one member of the interleukin-1 family,includes interleukin 36α,interleukin 36β,interleukin 36γ,and interleukin 36 receptor antagonist.The co-receptor is interleukin 36 receptor.Interleukin 36 shares homology with the interleukin-1 family and activates mitogen-activated protein kinases and nuclear factor-κB signaling pathways,which are involved in the development and progression of pulmonary inflammatory diseases.The naming,biological characteristics,receptors and signaling pathways of interleukin 36,and the relationship between pulmonary inflammatory diseases are reviewed.

关 键 词：白细胞介素36 信号转导 肺部炎症 白细胞介素1家族 

分 类 号：R563.1[医药卫生—呼吸系统]