纳米超粒子的制备、性质及其生物成像分析应用  

Fabrication,Properties and Bio-imaging Application of Supraparticles

作　　者：朱慧 夏云生[1] ZHU Hui;XIA Yun-Sheng(Key Laboratory of Functional Molecular Solids,Ministry of Education,College of Chemistry and Materials Science,Anhui Normal University,Wuhu 241000,China)

机构地区：[1]安徽师范大学化学与材料科学学院,功能分子固体教育部重点实验室,芜湖241000

出　　处：《分析化学》2021年第7期1089-1105,共17页Chinese Journal of Analytical Chemistry

基　　金：国家自然科学基金项目(No.21775004)资助。

摘　　要：纳米超粒子(Supraparticles,SPs)是指将相同或不同种类的无机纳米粒子单元,通过自组装形成具有一定形状和分级结构的纳米聚集体。SPs不仅具有新颖多样的集合性质和协同效应,并且其丰富可调的形貌与空间拓扑结构为其与各种生物系统的相互作用提供了多尺度和多维度的可能性,在生物传感、生物成像、疾病诊疗等领域具有广阔的应用前景。本文阐述了SPs的制备方法和性质,同时,对近期SPs在生物成像分析领域的应用进行了总结,最后,讨论了SPs在制备和生物医学应用领域中存在的主要问题及未来的发展前景。Supraparticles(SPs)are the nano-agglomerates with a certain shape and hierarchical structure,which are self-assembled by same or different kinds of individual inorganic nanocrystals.SPs not only exhibit collective properties and/or synergistic effects,but their diverse shapes and devisable spatial structures provide multi-scale and multi-dimensional possibilities for the interactions with various biological systems.Thus,SPs show a variety of application potentials in bio-sensing,bio-imaging,diagnosis and even therapy,etc.In this review,the progress of SPs fabrication,properties,and their applications in bioimaging field in recent years are summarized,and the main problems and future development of their fabrication and applications in bio-medicine are discussed.

关 键 词：纳米超粒子 制备 集合性质 协同效应 生物成像 评述 

分 类 号：TB383.1[一般工业技术—材料科学与工程]