“五个时刻法”延续用药指导在慢性乙型肝炎长期抗病毒治疗中的应用价值  

Application value of"5-moment method"continuous medication guidance in long-term antiviral therapy of chronic hepatitis B

作　　者：王蕾[1] 王丹[1] 李汝珂 李长安[1] 赵巍峰[1] WANG Lei;WANG Dan;LI Ruke;LI Chang′an;ZHAO Weifeng(Department of Infectious Diseases,the Third Affiliated Hospital of Xinxiang Medical University,Xinxiang 453000,Henan Province,China)

机构地区：[1]新乡医学院第三附属医院感染性疾病科,河南新乡453000

出　　处：《新乡医学院学报》2021年第6期526-530,共5页Journal of Xinxiang Medical University

基　　金：国家科技重大专项课题资助项目(编号:2013ZX10002005)。

摘　　要：目的探讨“五个时刻法”延续用药指导在慢性乙型肝炎(CHB)长期抗病毒治疗中的应用价值。方法选择2017年7月至2019年6月新乡医学院第三附属医院收治的102例CHB患者为研究对象,按照入院时间将患者分为观察组(n=50)和对照组(n=52)。2组患者均接受长期抗病毒治疗,对照组患者实施常规延续性用药指导,观察组患者实施“五个时刻法”延续性用药指导,对2组患者干预前及干预3、6、12个月时的Morisky用药依从性量表(MMAS-8)评分、服药依从率、一般自我效能感量表(GSES)评分、健康教育知识掌握程度进行比较;所有患者随访1 a,观察干预3、6、9、12个月时的复查率。结果干预前2组患者MMAS-8、GSES评分比较差异无统计学意义(P>0.05),2组患者干预3、6、12个月时MMAS-8、GSES评分均显著高于干预前(P<0.05),干预3、6、12个月时观察组患者MMAS-8、GSES评分均显著高于对照组(P<0.05)。干预前及干预3、6、12个月时,观察组患者服药依从率分别为24.00%(12/50)、86.00%(43/50)、90.00%(45/50)、92.00%(46/50),对照组患者服药依从率分别为28.85%(15/52)、67.31%(35/52)、69.23%(36/52)、71.15%(37/50);干预前2组患者服药依从率比较差异无统计学意义(P>0.05);2组患者干预3、6、12个月时服药依从率显著高于干预前(P<0.05);干预3、6、12个月时,观察组患者服药依从率显著高于对照组(P<0.05)。干预前2组患者健康教育知识评分比较差异无统计学意义(P>0.05),2组患者干预3、6、12个月时健康教育知识评分均显著高于干预前(P<0.05),干预3、6、12个月时观察组患者健康教育知识评分均显著高于对照组(P<0.05)。干预3、6、9、12个月时,观察组患者复查率分别为96.00%(48/50)、100.00%(50/50)、94.00%(47/50)、98.00%(49/50),对照组患者复查率分别为82.69%(43/52)、80.77%(42/52)、76.92%(40/52)、82.69%(43/52),干预3、6、9、12个月时观察组患者复查率均显著高于对照组(P<0.05Objective To investigate the application value of"5-moment method"continuous medication guidance in long-term antiviral therapy of chronic hepatitis B(CHB).Methods A total of 102 patients with CHB admitted to the Third Affiliated Hospital of Xinxiang Medical University from July 2017 to June 2019 were selected as the study subjects.The patients were divided into observation group(n=50)and control group(n=52)according to the admission time.The patients in the two groups received long-term antiviral therapy.The patients in the control group were given routine continuous medication guidance,while the patients in the observation group were given"5-moment method"continuous medication guidance.The Morisky medication adherence scale-8(MMAS-8)score,medication compliance rate,general self-efficacy scale(GSES)score and the acquisition of health education knowledge were compared between the two groups at pre-intervention and 3,6,12 months of intervention.All patients were followed up for one year,and the reexamination rate at 3,6,9 and 12 months of intervention were observed.Results There was no significant difference in the MMAS-8 and GSES scores between the two groups before intervention(P>0.05).The MMAS-8 and GSES scores at 3,6 and 12 months of intervention were significantly higher than those before intervention in the two groups(P<0.05).The MMAS-8 and GSES scores in the observation group were significantly higher than those in the control group at 3,6 and 12 months of intervention(P<0.05).Before intervention and 3,6,12 months after intervention,the medication compliance rate in the observation group was 24.00%(12/50),86.00%(43/50),90.00%(45/50),92.00%(46/50),respectively;while that in the control group was 28.85%(15/52),67.31%(35/52),69.23%(36/52),71.15%(37/50),respectively.There was no significant difference in medication compliance rate between the two groups before intervention(P>0.05).The medication compliance rate at 3,6 and 12 months of intervention were significantly higher than that before intervention in the t

关 键 词：慢性乙型肝炎 抗病毒治疗 用药指导 服药依从性 自我效能 

分 类 号：R453[医药卫生—治疗学]