Poly(α-L-lysine)-based nanomaterials for versatile biomedical applications:Current advances and perspectives  

作　　者：Maochao Zheng Miao Pan Wancong Zhang Huanchang Lin Shenlang Wu Chao Lu Shijie Tang Daojun Liu Jianfeng Cai 

机构地区：[1]Shantou University Medical College,22 Xinling Road,Shantou,515041,China [2]The Second Affiliated Hospital of Shantou University Medical College,69 Dongxiabei Road,Shantou,515041,China [3]College of Pharmacy,Jinan University,Guangzhou,511443,China [4]Department of Chemistry,University of South Florida,Tampa,FL,33620,USA

出　　处：《Bioactive Materials》2021年第7期1878-1909,共32页生物活性材料（英文）

基　　金：This work was financially supported by the National Natural Science Foundation of China,China(No.81803467);2020 Li Ka Shing Foundation Cross-Disciplinary Research Grant,Hong Kong(2020LKSFG18B,2020LKSFG02E);the grant for Key Disciplinary Project of Clinical Medicine under the Guangdong High-Level University Development Program,Guangdong,China(002-18120314,002-18120311).

摘　　要：Poly(α-L-lysine)(PLL)is a class of water-soluble,cationic biopolymer composed ofα-L-lysine structural units.The previous decade witnessed tremendous progress in the synthesis and biomedical applications of PLL and its composites.PLL-based polymers and copolymers,till date,have been extensively explored in the contexts such as antibacterial agents,gene/drug/protein delivery systems,bio-sensing,bio-imaging,and tissue engineering.This review aims to summarize the recent advances in PLL-based nanomaterials in these biomedical fields over the last decade.The review first describes the synthesis of PLL and its derivatives,followed by the main text of their recent biomedical applications and translational studies.Finally,the challenges and perspectives of PLL-based nanomaterials in biomedical fields are addressed.

关 键 词：Poly(α-L-lysine) Antimicrobial agents Delivery systems Bio-sensing BIO-IMAGING 

分 类 号：R318.08[医药卫生—生物医学工程]