青春期甲状腺功能亢进症对生长发育及精神状态的影响  

Influence of adolescent hyperthyroidism on adolescent growth and mental status

作　　者：戴红[1] 朱红霞[1] 董佳[1] 吴蕾[1] 贺威[1] 王秭萱 DAI Hong;ZHU Hongxia;DONG Jia;WU Lei;HE Wei;WAN Zixuan(The Second Department of Internal Medicine,Liaoning Provincial Corps Hospital,Chinese People's Armed Police Force,Shenyang 110034,China)

机构地区：[1]武警辽宁总队医院内二科,沈阳110034

出　　处：《武警医学》2020年第12期1049-1052,共4页Medical Journal of the Chinese People's Armed Police Force

摘　　要：目的探讨青春期甲状腺功能亢进症(甲亢)对生长发育及精神状态的影响。方法选择2017-01至2018-12武警辽宁总队医院就诊的青春期甲亢患者50例作为观察组,同期随机选择至该院体检的同年龄段青少年50例作为对照组。所有人员均测定身高、体重、甲状腺功能、血清Ca^(2+)、P^(2+)、ALP,进行PSQI、SAS、SDS问卷调查。比较两组的相关指标,并分析FT_(3)、FT_(4)、TSH水平与其他指标的相关性。结果观察组身高<-2 SD、体重<-2 SD、BMI<18.5(kg/m^(2))所占比例显著高于对照组,差异有统计学意义(P<0.05)。两组受试者的血清Ca^(2+)、P^(2+)水平无统计学差异,但观察组ALP水平、PSQI评分、SAS评分、SDS评分均高于对照组,观察组中PSQI≥16分、SAS≥50分、SDS≥53分所占比例亦显著高于对照组,差异有统计学意义(P<0.05)。Pearson相关性分析发现FT_(4)水平与PSQI评分、SAS评分、SDS评分呈正相关(P<0.05)。结论青春期甲亢影响青少年的生长发育和精神状态。Objective To analyze the influence of adolescent hyperthyroidism on the growth and mental status of adolescents.Methods Fifty patients with adolescent hyperthyroidism treated in our hospital between January 2017 and December 2018 were selected as the observation group,while another 50 adolescents of the same age were randomly selected as the control group.Height,weight,thyroid function,serum Ca^(2+),P^(2+),ALP were measured,and PSQI,SAS and SDS questionnaires were used.The related indexes were compared between the two groups,and the correlation between FT_(3),FT_(4),TSH and other indexes was analyzed.Results The proportions of height<-2 SD,weight<-2 SD and BMI<18.5(kg/m^(2))in the observation group were significantly higher than those in the control group(P<0.05).There were no significant difference in serum Ca^(2+) or P^(2+)levels between the two groups,but the ALP level in the observation group was significantly higher than that in the control group(P<0.05).The scores of PSQI,SAS and SDS in the observation group were higher than those of the control group.The proportion of PSQI≥16,SAS≥50,SDS≥53 in the observation group was also significantly higher than that in the control group(P<0.05).Pearson correlation analysis showed that the FT_(4) level was positively correlated with the scores of PSQI,SAS and SDS(P<0.05).Conclusions Adolescent hyperthyroidism can affect the growth,development and mental state of adolescents.Importance should be attached to the prevention and treatment of adolescent hyperthyroidism.

关 键 词：青春期 甲状腺功能亢进症 生长发育 睡眠障碍 焦虑 抑郁 

分 类 号：R581.1[医药卫生—内分泌]