上海地区儿童脉冲振荡肺功能预计值建立  

Establishment of predicted value of lung function determined by impulse oscillometry in children in Shanghai

作　　者：吴巾红 张皓[1] 董晓艳 黄剑峰 刘全华[4] 潘春红[1] 沈理 周小建[6] WU Jinhong;ZHANG Hao;DONG Xiaoyan;HUANG Jianfeng;LIU Quanhua;PAN Chunhong;SHEN Li;ZHOU Xiaojian(Department of Pulmonology,Shanghai Children's Medical Center Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200127,China;Department of Pulmonology,Shanghai Children’s Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200040,China;Department of Pulmonology,Children’s Hospital of Fudan University,Shanghai 201102,China;Department of Pulmonology,Xinhua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200092,China;Shanghai Jiao Tong University School of Medicine,Shanghai,200025,China;Department of Pediatrics,Shanghai First People's Hospital Affiliated to Shanghai Jiao Tong University,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属上海儿童医学中心呼吸科,上海200127 [2]上海交通大学附属上海儿童医院呼吸科,上海200040 [3]复旦大学附属儿科医院呼吸科,上海201102 [4]上海交通大学医学院附属新华医院小儿呼吸科,上海200092 [5]上海交通大学医学院,上海200025 [6]上海交通大学附属第一人民医院儿科,上海200080

出　　处：《临床儿科杂志》2021年第6期405-409,414,共6页Journal of Clinical Pediatrics

基　　金：上海市医学引导类(中、西医)科技支撑项目(No.19401931800);上海交通大学医学院中西医结合学科创新基金项目(No.18zxy007)。

摘　　要：目的建立上海地区5~11岁儿童脉冲震荡肺功能的预计值。方法纳入上海地区5~11岁的746名健康儿童,采用德国Jaeger公司生产的Master Screen IOS肺功能检测仪检测受试儿童平静呼吸状态下的呼吸总阻抗(Zrs)、响应频率(Fres)、不同振荡频率下的黏性阻力(Rrs)及弹性阻力(Xrs)等指标,并进行分析。经多元逐步回归建立不同性别脉冲振荡(IOS)相关参数的回归方程。结果746例儿童中男510例、女236例,年龄5~11岁,中位年龄8岁。5岁组男性身高高于女性,5~、7~、10~岁组男孩体质量均高于女孩,差异均有统计学意义(P<0.05)。无论男女,不同年龄、身高组之间IOS主要参数的差异均有统计学意义(P<0.05),Zrs、Fres、R_(5)和R_(20)数值随年龄和身高的增长而下降,而X_(5)则随着年龄和身高的增加逐渐增大。多元逐步回归分析发现,IOS参数与身高、年龄、体质量均有关,多数IOS参数与身高关系最为密切(回归系数绝对值最大)。结论建立了上海地区健康儿童脉冲震荡肺功能正常预计值;在肺功能检查评估中,采用该预计值方程式更符合中国儿童特点。Objective To establish the predicted value of lung function determined by impulse oscillometry(IOS)in children(5~11 years old)in Shanghai.Methods A total of 746 healthy children aged 5 to 11 in Shanghai were included.The Master Screen IOS pulmonary function device(Jaeger Co,Germany)was used to detect the respiratory total impedance(Zrs),response frequency(Fres),viscosity resistance(Rrs)and elastic resistance(Xrs)at various oscillation frequencies,and the indexes above were analyzed.The stepwise multivariate regression was used to establish the regression equation of related parameters of IOS in different genders.Results The median age of 746 children(510 boys and 236 girls)was 8 years,ranging from 5 to 11 years.The height of male in 5-year-old group was higher than that of female,and the weight of male in 5-,7- and 10-year-old group was higher than that of female,and the differences were statistically significant(P<0.05).The differences in the main IOS parameters between different age and height groups are statistically significant regardless of sex(P<0.05).The values of Zrs,Fres,R_(5) and R_(20) decreased with the increase of age and height,while X5 increased with the increase of age and height.The stepwise multivariate regression analysis showed that IOS parameters were related to height,age and weight,and most IOS parameters were most closely related to height(the absolute value of regression coefficient was the largest).Conclusions The study revealed the normal predicted value of pulmonary function by IOS in healthy children in Shanghai.In the evaluation of the results of the lung function measurements,the use of this predicted value equation is more in line with the characteristics of Chinese children than that of foreign countries.

关 键 词：脉冲震荡 肺功能检测 正常预计值 儿童 

分 类 号：R725.6[医药卫生—儿科]