Modified poly(methyl methacrylate) bone cement in the treatment of Kümmell disease  

作　　者：Jinjin Zhu Shuhui Yang Yute Yang Teng Yao Gang Liu Shunwu Fan He Zhao Fuzhai Cui Xiumei Wang Guoqiang Jiang Xiangqian Fang 

机构地区：[1]Department of Orthopaedic Surgery,Sir Run Run Shaw Hospital,Zhejiang University School of Medicine,Hangzhou 310016,China [2]Key Laboratory of Mus culoskeletal System Degeneration and Regeneration Translational Research of Zhejiang Province,Hangzhou 310016,China [3]State Key Laboratory of New Ceramics and Fine Processing,School of Materials Science and Engineering,Tsinghua University,Beijing 100084,China [4]Department of Spinal Surgery,The Afiliated Hospital of Medical School of Ningbo University,Ningbo 315020,China [5]Department of Orthopedics,Dongzhimen Hos pital,Beijing University of Chinese Medicine,Beijing 100700,China

出　　处：《Regenerative Biomaterials》2021年第1期1-9,共9页再生生物材料（英文版）

基　　金：This work was supported by National Key R&D Program of China(No.2018YFC1105202);the Key research and development plan in Zhejiang prov-ince(No.2020C03041);National Nature Science Fund of China(No.81871797);Natural Science Fund of Zhejiang Province(LY17H060001).

摘　　要：Kuümmell disease(KD)causes serious vertebral body collapse in patients.However,only a few case reports have been conducted and the number of patients with KD investigated was limited.Additionally,the frequently used poly(methyl methacrylate)(PMMA)bone cement for KD is limited by excessive modulus and poor biocompatibility.Herein,we aimed to modify PMMA bone cement with mineralized collagen(MC),and compare the clinical effects,image performance and finite ele-ment analysis between the modified bone cement and PMMA bone cement for the treatment of phase I and II KD.Thirty-nine KD patients treated with PMMA bone cement and 40 KD patients treated with MC-modified PMMA bone cement from June 2015 to March 2017 were retrospectively analyzed.The surgical procedure,intraoperative blood loss,hospital stay and complications were compared between different groups.Visual analog scale,Oswestry disability index,anterior verte-bral height,posterior vertebral height,computed tomography value,adjacent vertebral re-fracture,Cobb angle and wedge-shaped correction angle were evaluated.Additionally,the representative sample was selected for finite element analysis.We found that the MC-modified PMMA bone ce-ment could achieve the same effect as that of PMMA bone cement and was associated with better vertebral height restoration in the long term.

关 键 词：mineralized collagen poly(methylmethacrylate)bonecement Kümmelldisease MECHANICALPROPERTY 

分 类 号：R68[医药卫生—骨科学]