The study of dry biological valve crosslinked with a combination of carbodiimide and polyphenol  

作　　者：Li Yang Shuang Xie Kailei Ding Yang Lei YunbingWang 

机构地区：[1]National Engineering Research Centerfor Biomaterials,Sichuan University,No.29 Wangjiang Road,Chengdu 610064,China

出　　处：《Regenerative Biomaterials》2021年第1期83-91,共9页再生生物材料（英文版）

基　　金：This work was supported by the National Natural Science Foundation of China(No.31700833).

摘　　要：The glutaraldehyde crosslinked pericardium has been used in bioprosthetic valves for about 50 years.However,problems such as glutaraldehyde residue and calcification still exist in current commercial products.Non-glutar aldehyde crosslinked dry valve is an important strategy to solve those problems.In this study,a non-glutaraldehyde crosslinked dry biological valve material was obtained by the combined crosslinking of carbodimide(EDC)and polyphenol.The results showed that the comprehensive properties of EDC and curcumin crosslinked pericardium were superior to glutaraldehyde crosslinked pericardium,including unfolding property,anti-calcification,cytotoxicity,anticoagulant properties,mechanical properties,enzyme degradation resistance and thermal shrinkage temperature.EDC and curcumin crosslinked dry pericardium could flatten after being folded at 40℃ for 3 days while glutaraldehyde crosslinked pericardium could not.The calcification of pericardium treated with EDC and curcumin was 1.21±0.36 mg/g in rats after 60 days'subdermal implantation,much lower than that of glutaraldehyde treated control group(22.06±3.17 mg/g).

关 键 词：dry biological valve carbodimide polyphe nol non-glutraldehyde 

分 类 号：O63[理学—高分子化学]