Superabsorbent poly(acrylic acid) and antioxidant poly(ester amide) hybrid hydrogel for enhanced wound healing  

作　　者：Jianhua Zhang Junfei Hu Baoshu Chen Tianbao Zhao Zhipeng Gu 

机构地区：[1]School of Materials Science and Engineering,Xihua University,Chengdu 610039,P.R.China [2]College of Polymer Science and Engineering,State Key Laboratory of Polymer Materials Engineering,Sichuan University,Chengdu 610065,P.R.China [3]College of Chemistry,Sichuan University,Chengdu 610065,P.R.China [4]Yibin Tianyuan Grp Co.,Ltd.,Yibin,Sichuan Province 644000,P.R.China [5]Research Institute of Sun Yat-Sen University,Shenzhen 518057,P.R.China

出　　处：《Regenerative Biomaterials》2021年第2期26-33,共8页再生生物材料（英文版）

基　　金：This work sincerely acknowledges the support from the Science and Technology Planning Project of Shenzhen(JCYJ20190813153409172);Chunhui Project from Education Ministry of China(Z2016125);Sichuan Science and Technology Program(2019YFG0251,2019JDTD0024);Young scholars for reserve talents of Xihua University.

摘　　要：Wound healing dressing is increasingly needed in clinical owing to the large quantity of skin damage annually.Excessive reactive oxygen species(ROS)produced through internal or external environmental influences can lead to lipid peroxidation,protein denaturation,and even DNA damage,and ultimately have harmful effects on cells.Aiming to sufficiently contact with the wound microenvironment and scavenge ROS,superabsorbent poly(acrylic acid)and antioxidant poly(ester amide)(PAA/PEA)hybrid hydrogel has been developed to enhance wound healing.The physical and chemical properties of hybrid hydrogels were studied by Fourier-transform infrared(FTIR)absorption spectrum,compression,swelling,degradation,etc.Besides,the antioxidant properties of hybrid hydrogels can be investigated through the free radical scavenging experiment,and corresponding antioxidant indicators have been tested at the cellular level.Hybrid hydrogel scaffolds supported the proliferation of human umbilical vein endothelial cells and fibroblasts,as well as accelerated angiogenesis and skin regeneration in wounds.The healing properties of wounds in vivo were further assessed on mouse skin wounds.Results showed that PAA/PEA hybrid hydrogel scaffolds significantly accelerated the wound healing process through enhancing granulation formation and re-epithelialization.In summary,these superabsorbent and antioxidative hybrid hydrogels could be served as an excellent wound dressing for full-thickness wound healing.

关 键 词：poly(acrylic acid)/poly(ester amide) SUPERABSORBENT antioxidant wound healing 

分 类 号：O63[理学—高分子化学]