Tetraphenylethylene-conjugated polycation covered iron oxide nanoparticles for magnetic resonance/optical dual-mode imaging  

作　　者：Li Yang Shengxiang Fu Li Liu Zhongyuan Cai Chunchao Xia Bin Song Qiyong Gong Zhiyun Lu Hua Ai 

机构地区：[1]National Engineering Research Center for Biomaterials,Sichuan University,Chengdu 610065,China [2]Department of Radiology,West China Hospital,Sichuan University,Chengdu 610041,China [3]Huaxi MR Research Center(HMRRC),Department of Radiology,West China Hospital of Sichuan University,Chengdu,China [4]Psychoradiology Research Unit of Chinese Academy of Medical Sciences,Sichuan University,Chengdu,China [5]Key Laboratory of Green Chemistry and Technology(Ministry of Education),College of Chemistry,Sichuan University,Chengdu 610065,China

出　　处：《Regenerative Biomaterials》2021年第3期124-132,共9页再生生物材料（英文版）

基　　金：This work was financially supported by the National Natural Science Foundation of China(NSFC,No.51903174 and 52073192);Innovative Research Groups of the National Natural Science Foundation of China(81621003);Chengdu Science and Technology Program(2019-YF05-00318-SN);the Fundamental Research Funds for Central Universities(2021SCU12070).

摘　　要：Magnetic resonance(MR)/optical dual-mode imaging with high sensitivity and high tissue resolution have attracted many attentions in biomedical applications.To avert aggregation-caused quenching of conventional fluorescence chromophores,an aggregation-induced emission molecule tetraphenylethylene(TPE)-conjugated amphiphilic polyethylenimine(PEI)covered superparamagnetic iron oxide(Alkyl-PEI-LAC-TPE/SPIO nanocomposites)was prepared as an MR/optical dual-mode probe.Alkyl-PEI-LAC-TPE/SPIO nanocomposites exhibited good fluorescence property and presented higher T2 relaxivity(352 Fe mM1s1)than a commercial contrast agent Feridex(120 Fe mM1s1)at 1.5 T.The alkylation degree of Alkyl-PEI-LAC-TPE effects the restriction of intramolecular rotation process of TPE.Reducing alkane chain grafting ratio aggravated the stack of TPE,increasing the fluorescence lifetime of Alkyl-PEI-LAC-TPE/SPIO nanocomposites.Alkyl-PEI-LAC-TPE/SPIO nanocomposites can effectively labelled HeLa cells and resulted in high fluorescence intensity and excellent MR imaging sensitivity.As an MR/optical imaging probe,Alkyl-PEI-LAC-TPE/SPIO nanocomposites may be used in biomedical imaging for certain applications.

关 键 词：magnetic resonance imaging optical imaging superparamagnetic iron oxide aggregation-induced emission dual-mode imaging 

分 类 号：O62[理学—有机化学]