群体感应系统与生物膜耐药机制的研究现状  

Research status of quorum sensing system and mechanism of biofilm resistance

作　　者：董行 郎东浩 符雪 李芳[2] 王凌峰[2] Dong Hang;Lang Donghao;Fu Xue;Li Fang;Wang Lingfeng(Inner Mongolia Medical University,Huhhot 010000,China;Department of Burns,Baogang Hospital of Inner Mongolia Autonomous Region,Inner Mongolia Burn Research Institute,Baotou 014010,China)

机构地区：[1]内蒙古医科大学,呼和浩特010000 [2]内蒙古包钢医院烧伤外科内蒙古烧伤研究所,内蒙古包头014000

出　　处：《中华临床医师杂志（电子版）》2021年第1期57-60,共4页Chinese Journal of Clinicians(Electronic Edition)

基　　金：内蒙古自治区自然科学基金项目(2016MS0809);2019年度包头市青年创新人才项目。

摘　　要：群体感应(QS)系统是细菌调节群体生理行为的一种常见机制,与细菌本身密度相关。细菌QS系统对细菌生物膜耐药等许多特定的功能进行调节。通过对QS系统的研究,可以发现其在细菌耐药性的发生、发展中起着重要作用。因此,需要我们进一步研究细菌生物膜与QS系统的关系,了解QS系统在细菌生物膜中耐药性的发生机制,为临床提供新的治疗理念。本文对近些年QS系统对细菌生物膜耐药性调控作用的研究现状进行综述。Quorum sensing(QS)system is a common mechanism for bacteria to regulate the population physiological behavior,which is related to the density of bacteria.Bacterial QS system regulates many specific functions such as bacterial biofilm resistance.It has been found that the QS system plays an important role in the occurrence and development of bacterial resistance.Therefore,it is essential to further study the relationship between bacterial biofilm and the QS system and understand the role of the QS system in the development of drug resistance of bacterial biofilm,so as to provide a new therapeutic concept for clinical practice.In this paper,we review the role of the QS system in the regulation of bacterial biofilm resistance.

关 键 词：群体感应系统 细菌生物膜 耐药性 

分 类 号：R446.5[医药卫生—诊断学]