基于医学科研与临床应用的药物知识库研究进展  

Research progress of drug knowledge bases based on medical research and clinical application

作　　者：潘文洁 尹泽宇 侯婉馨 Jawad Hussain 张远鹏[1] 姚敏[5] 王理[2,3] Pan Wenjie;Yin Zeyu;Hou Wanxin;Jawad Hussain;Zhang Yuanpeng;Yao Min;Wang Li(Department of Medical Informatics,Medical School of Nantong University,Nantong 226001,China;School of Information Science and Technology,Nantong University,Nantong 226001,China;Research Center for Intelligence Information Technology,Nantong University,Nantong 226001,China;Nantong Research Institute for Advanced Communication Technologies,Nantong 226001,China;Department of Immunology,Medical School of Nantong University,Nantong 226001,China)

机构地区：[1]南通大学医学院医学信息学系,江苏南通226001 [2]南通大学信息科学技术学院,江苏南通226001 [3]南通大学智能信息技术研究中心,江苏南通226001 [4]南通先进通信技术研究院有限公司,江苏南通226001 [5]南通大学医学院免疫教研室,江苏南通226001

出　　处：《中华临床医师杂志（电子版）》2021年第1期72-78,共7页Chinese Journal of Clinicians(Electronic Edition)

基　　金：国家自然科学基金(81873915);科技部国家重点研发计划(2018YFC0116902);南通市科技项目(MS12020021)。

摘　　要：药物知识库是基于人工智能算法构建,用于整合现有药物知识和挖掘有效知识的知识库。目前,药物知识库已应用于抗菌药物监管、合理药物指导、健康管理干预和临床决策等临床活动中。同时,科研人员基于药物知识库进行如不良反应分析、药物重利用、耐药性研究和药物基因组研究等研究。本文就近年来有关药物知识库在科研和临床中的研究进展进行综述,希望为进一步探讨药物知识库的开发与利用带来新思路。The drug knowledge base is constructed based on artificial intelligence algorithms,which is used to integrate existing drug knowledge and tap effective knowledge.Currently,drug knowledge bases have been used in clinical research such as antimicrobial drug supervision,rational drug guidance,health management intervention,and clinical decision support.Based on the drug knowledge bases,researchers perform scientific research such as adverse drug reaction analysis,drug repurposing,drug resistance analysis,system pharmacogenomics analysis,and so on.In this paper,we review the progress of the drug knowledge bases in scientific and clinical research,in order to shed some light on the further application and development of the drug knowledge bases.

关 键 词：药物知识库 人工智能 医学应用 

分 类 号：R95[医药卫生—药学]