阿司匹林联合不同剂量的静脉注射用人免疫球蛋白对非典型川崎病的治疗效果及其对免疫功能的影响  

Therapeutic efficacy of aspirin combined with different doses of intravenous immunoglobulin on atypical Kawasaki disease and its impacts on immunologic function

作　　者：张媛昊 ZHANG Yuanhao(Department of Pediatrics,People's Hospital of Anshun City in Guizhou Province,Guizhou,Anshun 561000,China)

机构地区：[1]贵州省安顺市人民医院儿科,贵州安顺561000

出　　处：《中国医药科学》2021年第11期94-97,共4页China Medicine And Pharmacy

摘　　要：目的探讨阿司匹林联合不同剂量的静脉注射用人免疫球蛋白(IVIG)对非典型川崎病患儿的治疗效果及其对患儿免疫功能的影响。方法选取2014年1月至2020年9月于贵州省安顺市人民医院儿科接受治疗的非典型川崎病患儿100例,按照完全随机法分为IVIG常规疗法组、IVIG冲击疗法组各50例,在口服阿司匹林的基础上,IVIG常规疗法组患儿使用IVIG进行治疗[400 mg/(kg·d)×5 d],IVIG冲击疗法组患儿使用IVIG冲击治疗(2 g/kg)。对比两组患儿临床症状消失时间、冠状动脉病变发生率、PLT、WBC、ESR、免疫球蛋白(IgA、IgM、IgG)水平。结果冲击疗法组患儿各种临床症状消失时间均短于常规疗法组(P<0.05),冲击疗法组患儿冠状动脉病变发生率为14.00%,显著低于常规疗法组患儿的32.00%(P<0.05)。治疗后冲击疗法组患儿ESR、PLT、WBC、免疫球蛋白水平低于常规疗法组(P<0.05)。结论采用阿司匹林联合IVIG冲击疗法对非典型川崎病患儿进行治疗,能够加快患儿临床症状消失的时间,降低冠状动脉病变的发生率,降低患儿ESR、PLT、WBC、免疫球蛋白水平,从而改善患儿的临床症状及免疫功能,治疗效果显著。Objective To investigate the therapeutic efficacy of as pirin combined with different doses of intravenous immunoglobulin(IVIG)on children with atypical Kawasaki disease and its impacts on children's immunologic function.Methods A total of 100 children with atypical Kawasaki disease who were treated in the Department of Pediatrics of People's Hospital of Anshun City in Guizhou Province from January 2014 to September 2020 were selected,and they were divided into the IVIG conventional therapy group(n=50)and the IVIG impulse therapy group(n=50)according to the completely random method.On the basis of oral aspirin,children in the IVIG conventional therapy group were treated with IVIG(400 mg/[kg·d]×5 d),while those in the IVIG impulse therapy group were treated with IVIG impulse therapy(2 g/kg).The disappearance time of clinical symptoms,the incidence of coronary artery disease,the levels of PLT,WBC,ESR and immunoglobulin(IgA,IgM,IgG)were compared between the two groups of children.Results The disappearance time of various clinical symptoms in the impulse therapy group were all shorter than those in the conventional therapy group(P<0.05),and the incidence of coronary artery disease in children of the impulse therapy group was 14.00%,which was significantly lower than 32.00%of the conventional therapy group(P<0.05).After treatment,the levels of ESR,PLT,WBC and immunoglobulin in the impulse therapy group were lower than those in the conventional therapy group(P<0.05).Conclusion Aspirin combined with IVIG impulse therapy in the treatment of children with atypical Kawasaki disease can accelerate the disappearance time of clinical symptoms,reduce the incidence of coronary artery disease,and decrease the levels of ESR,PLT,WBC and immunoglobulin in children,thus improving the clinical symptoms and immunologic function of children.Therefore,the therapeutic efficacy is remarkable.

关 键 词：阿司匹林 静脉注射用人免疫球蛋白 非典型川崎病 免疫功能 

分 类 号：R725.9[医药卫生—儿科]