猪肺磷脂注射液联合经鼻持续气道正压通气治疗新生儿呼吸窘迫综合征的疗效研究  

Study on the efficacy of poractant alfa injection combined with nasal continuous positive airway pressure in the treatment of neonatal respiratory distress syndrome

作　　者：郑惠英 胡伟琼 ZHENG Hui-ying;HU Wei-qiong(Lufeng Maternal and Child Health Hospital,Shanwei 516500,China)

机构地区：[1]陆丰市妇幼保健院,516500

出　　处：《中国现代药物应用》2021年第12期145-147,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探究猪肺磷脂注射液联合经鼻持续气道正压通气(nCPAP)治疗新生儿呼吸窘迫综合征的临床效果。方法 60例新生儿呼吸窘迫综合征患儿,按照随机数字表法分为常规组和研究组,各30例。常规组给予猪肺磷脂注射液联合气管插管有创呼吸机机治疗,研究组给予猪肺磷脂联合nCPAP治疗。比较两组治疗前后血气分析指标[动脉氧分压(PaO_(2))、动脉二氧化碳分压(PaCO_(2))、pH值]及通气时间、症状持续时间、氧疗时间、并发症(肺气漏、肺出血、腹部胀气、呼吸机相关性肺炎)发生率。结果治疗后,常规组和研究组PaO_(2)、PaCO_(2)、pH值均优于治疗前,差异有统计学意义(P<0.05);治疗前和治疗后,常规组和研究组PaO_(2)、PaCO_(2)、pH值组间比较,差异均无统计学意义(P>0.05)。研究组通气时间(24.26±1.59)h、症状缓解时间(14.16±0.38)h、氧疗时间(65.21±1.02)h均短于常规组的(36.36±1.26)、(15.63±0.56)、(85.26±1.25)h,差异有统计学意义(P<0.05)。研究组并发症发生率明显低于常规组,差异有统计学意义(P<0.05)。结论采用猪肺磷脂注射液联合nCPAP治疗新生儿呼吸窘迫综合征,可显著缩短患儿的通气、氧疗时间,快速改善其临床症状,减少并发症风险,治疗效果理想。Objective To investigate the clinical effect of poractant alfa injection combined with nasal continuous positive airway pressure(nCPAP)in the treatment of neonatal respiratory distress syndrome.Methods A total of 60 cases of neonatal respiratory distress syndrome were divided into conventional group and research group according to random numerical table,with 30 cases in each group.The conventional group was treated with poractant alfa injection and tracheal intubation invasive ventilator,and the research group was treated with poractant alfa injection and nCPAP.The blood gas analysis indexes[arterial partial pressure of oxygen(PaO_(2)),arterial partial pressure of carbon dioxide(PaCO_(2)),pH value]before and after treatment,ventilation time,duration of symptoms,duration of oxygen therapy,occurrence of complications(pulmonary leakage,pulmonary hemorrhage,abdominal flatulence,ventilator associated pneumonia)were compared between the two groups.Results After treatment,the PaO_(2),PaCO_(2),pH value of the conventional group and research group were better than those before treatment,and the difference was statistically significant(P<0.05).Before and after treatment,there was no statistically significant difference in PaO_(2),PaCO_(2),pH value between the conventional group and research group(P>0.05).The ventilation time(24.26±1.59)h,duration of symptoms(14.16±0.38)h and duration of oxygen therapy(65.21±1.02)h of the research group were shorter than(36.36±1.26),(15.63±0.56)and(85.26±1.25)h of the conventional group,and the difference was statistically significant(P<0.05).The incidence of complications of the research group was obviously lower than that of the conventional group,and the difference was statistically significant(P<0.05).Conclusion Combination of poractant alfa injection and nCPAP shows ideal therapeutic effect on neonatal respiratory distress syndrome,and it can significantly shorten time of ventilation and oxygen therapy,improve the clinical symptoms and reduce the risk of complications.

关 键 词：猪肺磷脂注射液 经鼻持续气道正压通气 新生儿呼吸窘迫综合征 气管插管有创呼吸机 

分 类 号：R722.1[医药卫生—儿科]