Polydopamine/poly(sulfobetaine methacrylate)Co-deposition coatings triggered by CuSO_(4)/H_(2)O_(2)on implants for improved surface hemocompatibility and antibacterial activity  

作　　者：Zhongqiang Zhu Qiang Gao Ziyue Long Qiuyi Huo Yifan Ge Ntakirutimana Vianney Nishimwe Anodine Daliko Yongchun Meng Jia Qu Hao Chen Bailiang Wang 

机构地区：[1]School of Ophthalmology&Optometry,Eye Hospital,Wenzhou Medical University,Wenzhou,325027,China [2]Central Laboratory,Yantai Affiliated Hospital of Binzhou Medical University,717 Jinbu Street,Yantai,Shandong,264100,China

出　　处：《Bioactive Materials》2021年第8期2546-2556,共11页生物活性材料（英文）

基　　金：supported by the National Natural Science Foundation of China(31771026,82072077);Zhejiang Provincial Natural Science Foundation of China(LR19H180001);Project of State Key Laboratory of Ophthalmology,Optometry and Visual Science,Wenzhou Medical University(J02-20190203);Wenzhou key program of scientific and technological innovation(ZY2019017);Natural Science Foundation of Shandong Province of China(NO.ZR2016CQ16);Science and Technology Development Plan of Shandong Province of China(2020YD096)which are greatly acknowledged.

摘　　要：Implanted biomaterials such as medical catheters are prone to be adhered by proteins,platelets and bacteria due to their surface hydrophobicity characteristics,and then induce related infections and thrombosis.Hence,the development of a versatile strategy to endow surfaces with antibacterial and antifouling functions is particularly significant for blood-contacting materials.In this work,CuSO_(4)/H_(2)O_(2)was used to trigger polydopamine(PDA)and poly-(sulfobetaine methacrylate)(PSBMA)co-deposition process to endow polyurethane(PU)antibacterial and antifouling surface(PU/PDA(Cu)/PSBMA).The zwitterions contained in the PU/PDA(Cu)/PSBMA coating can significantly improve surface wettability to reduce protein adsorption,thereby improving its blood compatibility.In addition,the copper ions released from the metal-phenolic networks(MPNs)imparted them more than 90%antibacterial activity against E.coli and S.aureus.Notably,PU/PDA(Cu)/PSBMA also exhibits excellent performance in vivo mouse catheter-related infections models.Thus,the PU/PDA(Cu)/PSBMA has great application potential for developing multifunctional surface coatings for blood-contacting materials so as to improve antibacterial and anticoagulant properties.

关 键 词：Zwitterionic polymer Copper ions Surface modification Hemocompatibility ANTIBACTERIAL 

分 类 号：R318.08[医药卫生—生物医学工程]