Selection of different endothelialization modes and different seed cells for tissue-engineered vascular graft  

作　　者：Qingjin Cai Wanshan Liao Fangchao Xue Xiaochen Wang Weiming Zhou Yanzhao Li Wen Zeng 

机构地区：[1]Department of Cell Biology,Third Military Medical University,Chongqing,400038,China [2]State Key Laboratory of Trauma,Burn and Combined Injury,Chongqing,China [3]Departments of Neurology,Southwest Hospital,Third Military Medical University,Chongqing,China

出　　处：《Bioactive Materials》2021年第8期2557-2568,共12页生物活性材料（英文）

基　　金：supported by The National Science Fund for Outstanding Young Scholars(No:31822021);The Key Research and Development Plan Young Scientists Program(No:2017YFA0106000);The National Key Research and Development Plan(No:2016YFC1101100);National Science Foundation of China(No:31771057).

摘　　要：Tissue-engineered vascular grafts(TEVGs)have enormous potential for vascular replacement therapy.However,thrombosis and intimal hyperplasia are important problems associated with TEVGs especially small diameter TEVGs(<6 mm)after transplantation.Endothelialization of TEVGs is a key point to prevent thrombosis.Here,we discuss different types of endothelialization and different seed cells of tissue-engineered vascular grafts.Meanwhile,endothelial heterogeneity is also discussed.Based on it,we provide a new perspective for selecting suitable types of endothelialization and suitable seed cells to improve the long-term patency rate of tissue-engineered vascular grafts with different diameters and lengths.

关 键 词：Tissue-engineered vascular grafts scaffold materials seed cells vascular endothelialization endothelial heterogeneity 

分 类 号：R622.4[医药卫生—整形外科]