疟疾疫苗研制及其存在的问题  

Development of malaria vaccines and the challenges

作　　者：陈穗林 刘太平 徐文岳 CHEN Sui-lin;LIU Tai-ping;XU Wen-yue(Department of Pathogenic Biology,Army Medical University,Chongqing 400038,China)

机构地区：[1]陆军军医大学基础医学院病原生物学教研室,重庆400038

出　　处：《中国寄生虫学与寄生虫病杂志》2021年第3期283-295,共13页Chinese Journal of Parasitology and Parasitic Diseases

基　　金：国家自然科学基金重点项目(81830067);国家自然科学基金面上项目(82072299)。

摘　　要：历史上,传染病的最终控制和消除均得益于有效疫苗的接种。60多年来,研究者们一直致力于有效疟疾疫苗的研制。近年来,亚单位疟疾疫苗RTS,S和减毒子孢子疫苗的临床试验效果使研究者们看到了研制安全、有效疟疾疫苗的希望。然而,有效疟疾疫苗的最终研制成功还存在诸多的技术问题和理论瓶颈。本文从疟原虫的生物学及其感染免疫学特点角度对目前疟疾疫苗研制过程中所面临的问题进行分析,以期为有效疟疾疫苗的最终研制成功提供参考和努力的方向。Historically,the ultimate control and elimination of infectious diseases were all attributed to the inoculation of vaccines.For more than 60 years,scientists have never stopped their efforts on developing effective malaria vaccines.Recently,clinical trials on subunit vaccine RTS,S and attenuated sporozoite vaccine have shedded light on production of a safe and effective malaria vaccines.However,there are still many technical and theoretical bottlenecks that hinder the final development of effective malaria vaccine.In this paper,we analyze the problems currently encountered in the malaria vaccine development process from the view point of biological and immunological characteristics of Plasmodium spp.,in the hope to provide clues and directions for the ultimate development of effective malaria vaccines.

关 键 词：疟疾 疫苗 红外期 红内期 蚊期 

分 类 号：R531.3[医药卫生—内科学]