河南省洛阳市1例新发本地内脏利什曼病病例的流行病学调查  

Epidemiological investigation on a new local case of visceral leishmaniasis in Luoyang City,Henan Province

作　　者：李云霞[1] 程睿 周瑞敏[2] 杨成运[2] 张红卫[2] 田利光[3] 艾琳[3] LI Yun-xia;CHENG Rui;ZHOU Rui-min;YANG Cheng-yun;ZHANG Hong-wei;TIAN Li-guang;AI Lin(Luoyang Center for Disease Control and Prevention,Luoyang 471023,China;Henan Center for Disease Control and Prevention,Zhengzhou 410105;National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention(Chinese Center for Tropical Diseases Research),NHC Key Laboratory of Parasite and Vector Biology(National Institute of Parasitic Diseases,Chinese Center for Disease Control and Prevention),Shanghai 200025,China)

机构地区：[1]洛阳市疾病预防控制中心,洛阳471023 [2]河南省疾病预防控制中心,郑州450016 [3]中国疾病预防控制中心寄生虫病预防控制所(国家热带病研究中心)国家卫生健康委员会寄生虫病原与媒介生物学重点实验室(中国疾病预防控制中心寄生虫病预防控制所),上海200025

出　　处：《中国寄生虫学与寄生虫病杂志》2021年第3期410-413,共4页Chinese Journal of Parasitology and Parasitic Diseases

摘　　要：采用流行病学调查方法,调查2020年洛阳市1例新发生的内脏利什曼病患儿的发病经过和可能的感染来源,监测可疑人群和可疑犬只,并对可疑对象进行r K39抗体和PCR检测,调查监测村庄环境中的内脏利什曼病媒介白蛉,根据传染源、白蛉孳生环境及媒介分布评估传播风险。调查监测结果显示,患儿居住地洛阳市高新区引驾沟七组犬只r K39抗体阳性率为27.27%(9/33),全村住户的所有犬只r K39抗体阳性率为7.60%(13/171);患者的居住村内查见媒介中华白蛉。患儿及病犬的血样经PCR检测,扩增出的序列与婴儿利什曼原虫相应序列的相似性均为99%。本例病例为洛阳市60年来首个新发生的本地内脏利什曼病病例,患者从病犬获得感染的可能性较大。提示内脏利什曼病在本地存在较高的传播风险,需进一步对周边县区扩大监测并采取防控措施,以防止内脏利什曼病续发传播。Epidemiological investigation was performed for a new case of child visceral leishmaniasis occurred in Luoyang City in 2020,to analyze the course of the disease and the possible source of infection,and monitor the residents of and dogs of dubious infection.r K39 antibody detection and PCR assay were conducted in the suspected subjects;sandflies in the village environment were investigated and monitored.The transmission risk was assessed ac-cording to the source of infection,sandfly breeding environment and vector distribution.The results of investigation and monitoring showed that the positive rate of r K39 antibody was 27.27%(9/33)in 7 groups of dogs examined in the child’s residency area,Yinjiagou of High Tech District of Luoyang City,and the positive rate of r K39 antibody was7.60%(13/171)in the residents of the village.Sandflies were found in the village where the patient lived.The PCR assay of blood samples indicated the amplified sequences from thepatient and infected dogs showed 99%similarity to that of Leishmania infantis.This case was the first local visceral leishmanian case in Luoyang City over the past 60 years.It was highly likely that the patient was infected from infected dog.These results suggest that there is a high risk of local of visceral leishmaniasis in the area.It is imperative to scale-up the surveillance and strengthen prevention and control measures in the areas of surrounding counties to prevent further spread of visceral leishmaniasis.

关 键 词：内脏利什曼病 流行病学调查 白蛉 监测 

分 类 号：R531.6[医药卫生—内科学]