氧化石墨烯-壳聚糖复合膜修饰电极测定尿酸  

Determination of Uric Acid by Graphene Oxide-Chitosan Modified Electrode

作　　者：樊雪梅 王书民 李哲建 王毅梦 刘萍 范新会 FAN Xuemei;WANG Shumin;LI Zhejian;WANG Yimeng;LIU Ping;FAN Xinhui(College of Chemical Engineering and Modern Materials of Shangluo University,Shangluo 726000;School of Materials and Chemical Engineering,Xi’an Technological University,Xi’an 710021)

机构地区：[1]商洛学院化学工程与现代材料学院,陕西商洛726000 [2]西安工业大学材料与化学工程学院,陕西西安710021

出　　处：《分析科学学报》2021年第3期361-364,共4页Journal of Analytical Science

基　　金：国家自然科学基金(No.30970696);陕西省科技统筹创新工程计划(No.2012KTDZ02-02);陕西省科技厅项目(2018JM2040);商洛学院科技创新团队项目(No.18SCX003)。

摘　　要：通过自组装技术,制备了氧化石墨烯-壳聚糖复合膜修饰电极,并研究了尿酸在该修饰电极上的电化学行为。实验表明:该修饰电极对尿酸有较强的电催化作用,分别于电位0.615 V和0.446 V处出现一氧化峰和还原峰。利用差分脉冲伏安技术测定,尿酸浓度在5.0×10^(-6)~3.0×10^(-4) mol/L范围内与其氧化峰电流呈良好的线性关系,其相关系数R=0.9989,检出限为1.0×10^(-7) mol/L。该方法可用于尿液中尿酸含量的测定。The graphene oxide-chitosan(GO-CS)composite film modified electrode was prepared by the self-assembly technique.The research showed that uric acid had a good electrochemical behavior on the GO-CS modified electrode.A pair of oxidation and reduction peaks were appeared at 0.615 V and 0.446 V,respectively.The oxidation peak current was linear with the concentration of uric acid in the range of 5.0×10^(-6)-3.0×10^(-4) mol/L with a detection limit of 1.0×10^(-7) mol/L.The correlation coefficient was 0.9989.The proposed method was applied to the determination of UA in human urine samples with satisfactory results.

关 键 词：氧化石墨烯 壳聚糖 尿酸 

分 类 号：O657.15[理学—分析化学]